Diet, Asthma, and Severe Asthma Exacerbations in a Prospective Study of Puerto Rican Youth

Reyes-Angel, Jessica; Han, Yueh‐Ying; Rosser, Franziska; Forno, Erick; Acosta‐Pérez, Edna; Canino, Glorisa; Celedón, Juan C.

doi:10.1016/j.jaip.2022.01.029

Cited by 5 publications

(7 citation statements)

References 27 publications

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“…Logistic regression was used for the multivariable analysis of ETV or CCDS score and asthma among subjects with high Th2 immunity in PR-GOAL and EVA-PR, with statistical models developed using a Age in years 11.6 ± 1.9 11.5 ± 1.8 11.9 ± 1.9 Following a similar approach to recent analyses in PROPRA, 23,30 ETV or CCDS score was classified as below the median at both visits, at or above the median in the first visit (in PR-GOAL) but not in the second visit (in EVA-PR), at or above the median at the second visit but not at the first visit, and at or above the median at both visits. The outcome of interest was asthma at the second visit.…”

Section: Discussionmentioning

confidence: 99%

“…The child's caretaker (usually [>93%] the mother) or the study participant (if ≥18 years) completed a questionnaire on demographics and respiratory health; and a semiquantitative food frequency questionnaire (FFQ) developed for Hispanic populations 20–22 . Using this FFQ, we derived a dietary score (range: −2 to +2), and an unhealthy diet was defined as a score ≤ 0 23 . Lifetime ETV was assessed using the ETV scale, an 8‐item validated questionnaire on witnessing violence, witnessing domestic violence, and being the victim of violence 24,25 .…”

Section: Methodsmentioning

confidence: 99%

“…Following a similar approach to recent analyses in PROPRA, 23,30 ETV or CCDS score was classified as below the median at both visits, at or above the median in the first visit (in PR‐GOAL) but not in the second visit (in EVA‐PR), at or above the median at the second visit but not at the first visit, and at or above the median at both visits. The outcome of interest was asthma at the second visit.…”

Section: Methodsmentioning

confidence: 99%

“…[20][21][22] Using this FFQ, we derived a dietary score (range: −2 to +2), and an unhealthy diet was defined as a score ≤ 0. 23 Lifetime ETV was assessed using the ETV scale, an 8-item validated questionnaire on witnessing violence, witnessing domestic violence, and being the victim of violence. 24,25 An ETV summary score (range = 0−15) is obtained by summing the scores for each section.…”

Section: Introduction Asthma Affects Approximately 252 Million People...mentioning

confidence: 99%

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Exposure to violence and asthma in Puerto Rican youth with high Th2 immunity

Gaietto

Han

Forno

et al. 2023

Pediatric Pulmonology

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Background: Little is known about the determinants of asthma among youth with high T helper 2 (Th2) immunity. We hypothesized that exposure to violence (ETV) and violence-related distress are associated with asthma in children and adolescents with high Th2 immunity. Methods:We analyzed data from Puerto Ricans with high Th2 immunity aged 9−20 years in the Puerto Rico Genetics of Asthma and Lifestyle (PR-GOAL) and the Epigenetic Variation of Childhood Asthma in Puerto Ricans (EVA-PR) studies, and in a prospective study (PROPRA). High Th2-immunity was defined as ≥1 positive allergenspecific IgE and/or a total IgE ≥ 100 IU/mL and/or an eosinophil count ≥ 150 cells/μL. Asthma was defined as physician-diagnosed asthma and current wheeze. ETV and violence-related distress were assessed with the validated ETV Scale and Checklist of Children's Distress Symptoms (CCDS) questionnaires, respectively.Results: In multivariable analyses, each 1-point increment in ETV score was significantly associated with 1.13−1.17 times increased odds of asthma in PR-GOAL and in EVA-PR (both at p ≤ 0.01), and each 1-point increment in CCDS score was significantly associated with 1.53-1.54 increased odds of asthma in PR-GOAL and in EVA-PR (both at p ≤ 0.03). Further, a persistently high ETV score was significantly associated with asthma in PROPRA (odds ratio [OR] = 2.83, 95% confidence interval [CI] = 1.10−7.29). Similar results were obtained in a sensitivity analysis using an eosinophil count ≥ 300 cells/μL instead of ≥150 cells/μL to define high Th2 immunity.Conclusions: ETV during childhood is associated with increased risk of persistent or new-onset asthma in youth with high Th2 immunity.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introduction Asthma Affects Approximately 252 Million People...mentioning

confidence: 99%

See 2 more Smart Citations

Exposure to violence and asthma in Puerto Rican youth with high Th2 immunity

Gaietto

Han

Forno

et al. 2023

Pediatric Pulmonology

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show abstract

“…Our exposures of interest included social, physical, and individual determinants of health, namely, age, sex, low annual household income (<$15,000 per year, which was the median household income in Puerto Rico in 2008), type of health insurance (private or employer-based vs others), low parental education level (defined as neither parent having completed high school), low parental numeracy level (as in prior work, defined as an Asthma Numeracy Questionnaire score of 1 or lower), 26 parental history of asthma, prematurity, current SHS exposure, SHS in early life ( in utero or in the first 2 years of life), having a pet in the home, sighting of pests or mold in the home, overweight or obesity (body mass index z score ≥ 85th percentile), an unhealthy diet (as in prior work, defined as a nonpositive score (0, –1, or –2), 27 , 28 residential proximity to a major road, inhaled corticosteroid (ICS) use within the prior 6 months, and low or moderate level of physical outdoor activity. In the longitudinal analyses, we examined persistent exposure to determinants of health that could change between visits.…”

Section: Methodsmentioning

confidence: 99%