Diet as an epigenetic factor in inflammatory bowel disease

Marangoni, Karina; Dorneles, Gilson; da Silva, Daniella Miranda; Pinto, Letícia Pereira; Rossoni, Carina; Fernandes, Sabrina Alves

doi:10.3748/wjg.v29.i41.5618

Cited by 5 publications

(5 citation statements)

References 83 publications

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“…As highlighted in a study by Marangoni et al [ 4 ] published in World J Gastroenterol [ 4 ], DNA methylation is an essential remodeling process in the control of genetic information, which contributes to the epigenetics by regulating gene expression. DNA methylation and histone modifications are two central epigenetic mechanisms that impact gene transcription and cell fate.…”

Section: Diet As Epigenetic Factor In Inflammatory Bowel Diseasementioning

confidence: 99%

“…DNA methylation and histone modifications are two central epigenetic mechanisms that impact gene transcription and cell fate. The authors emphasize the role of diet, gut microbiota composition, and exercise in activation and modification of epigenetic mechanisms through the individual’s genetic inheritance[ 4 , 5 ]. An anti-inflammatory diet, by acting on gut microbiota composition, can induce phenotype changes through gene expression without changing the genetic sequence.…”

Section: Diet As Epigenetic Factor In Inflammatory Bowel Diseasementioning

confidence: 99%

“…Marangoni et al [ 4 ] also highlights the impact of non-coding RNA molecules that play a crucial role in the gene transcription and translation by non-coding RNAs[ 4 ]. Non-coding RNAs are RNAs not involved in protein translation, and they are divided into two categories by size, which include short and long non-coding RNAs[ 10 ].…”

Section: Diet As Epigenetic Factor In Inflammatory Bowel Diseasementioning

confidence: 99%

“…Dysbiosis, following exposure to an inflammatory diet and other environmental factors, leads to the activation of IBD genes via hypomethylation and histone modification. Westernized dietary risk factors like deficiencies in micronutrients, and being rich in ultra-processed foods, additives, and emulsifiers[ 13 ] are implicated in reducing bacterial diversity and promoting an inflammatory response[ 4 , 14 ] (Figure 1 ).…”

Section: Diet As Epigenetic Factor In Inflammatory Bowel Diseasementioning

confidence: 99%

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Pro and anti-inflammatory diets as strong epigenetic factors in inflammatory bowel disease

Rostami,

White,

Rostami

2024

World J Gastroenterol

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Inflammatory bowel disease (IBD) is the consequence of a complex interplay between environmental factors, like dietary habits, that alter intestinal microbiota in response to luminal antigens in genetically susceptible individuals. Epigenetics represents an auspicious area for the discovery of how environmental factors influence the pathogenesis of inflammation, prognosis, and response to therapy. Consequently, it relates to gene expression control in response to environmental influences. The increasing number of patients with IBD globally is indicative of the negative effects of a food supply rich in trans and saturated fats, refined sugars, starches and additives, as well as other environmental factors like sedentarism and excess bodyweight, influencing the promotion of gene expression and increasing DNA hypomethylation in IBD. As many genetic variants are now associated with Crohn's disease (CD), new therapeutic strategies targeting modifiable environmental triggers, such as the implementation of an anti-inflammatory diet that involves the removal of potential food antigens, are of growing interest in the current literature. Diet, as a strong epigenetic factor in the pathogenesis of inflammatory disorders like IBD, provides novel insights into the pathophysiology of intestinal and extraintestinal inflammatory disorders.

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Section: Diet As Epigenetic Factor In Inflammatory Bowel Diseasementioning

confidence: 99%

Section: Diet As Epigenetic Factor In Inflammatory Bowel Diseasementioning

confidence: 99%

Section: Diet As Epigenetic Factor In Inflammatory Bowel Diseasementioning

confidence: 99%

Section: Diet As Epigenetic Factor In Inflammatory Bowel Diseasementioning

confidence: 99%

See 2 more Smart Citations

Pro and anti-inflammatory diets as strong epigenetic factors in inflammatory bowel disease

Rostami,

White,

Rostami

2024

World J Gastroenterol

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“…Within circulation, polyphenols and metabolites can bind to immune cells. Polyphenols may modulate epigenetics by way of DNA methylation, histone modification and miRNA expression (Marangoni et al, 2023). This has been quantified by the use of epigenetic methylation analysis of immune cell composition through the use of well-respected machine learning algorithms.…”

Section: Introductionmentioning

confidence: 99%

The Impact of a Polyphenol-Rich Supplement on Epigenetic and Cellular Markers of Immune Age: A Pilot Clinical Study

Perlmutter,

Bland,

Chandra

et al. 2024

Preprint

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Age-related alterations in immune function are believed to increase risk for a host of age-related diseases leading to premature death and disability. Programming of the immune system by diet, lifestyle, and environmental factors occurs across the lifespan and influences both makeup and function of the immune system. This programming is believed to act in large part through epigenetic modification.One group of dietary molecules linked to generally healthier aging and relative immune resilience and homeostasis are polyphenols, which are consumed by humans primarily in the form of plant foods. While polyphenols are widely distributed throughout the plant and fungal kingdoms, certain foods are known to possess distinctive and relatively higher levels of these compounds. One such food is Tartary buckwheat (fagopyrum tataricum), an ancient seed historically prized for its health benefits. It is suggested that the specific composition of polyphenols found in foods like Tartary buckwheat may lead to a unique impact on longevity-related physiological pathways that could be interrogated through immune and epigenetic analyses.The objective of this study was to investigate the epigenetic effects on peripheral immune cells in healthy individuals of a standardized polyphenol concentrate based on naturally occurring nutrients in Tartary buckwheat. A pilot clinical trial was designed to test the effects of consuming 90 days of this concentrate on immune cell epigenetic methylation patterns and immune cell phenotypes in 50 healthy male (40%) and female (60%) participants aged 18-85 years using epigenetic age clocks and deconvolution methods. Analysis revealed significant intervention-related changes in multiple epigenetic age clocks and immune markers as well as population-wide alterations in gene ontology (GO) pathways related to longevity and immunity. This study provides previously unidentified insights into the immune, longevity and epigenetic effects of consumption of polyphenol-rich plants and generates additional support for health interventions built around historically consumed plants like Tartary buckwheat while offering compelling opportunities for additional research.

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Enhanced Transcription of Human Endogenous Retroviruses and TRIM28 Downregulation in Patients with Inflammatory Bowel Disease

Tovo,

Ribaldone,

Galliano

et al. 2024

Viruses

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Inflammatory bowel disease (IBD) includes patients affected by Crohn’s disease or ulcerative colitis. IBD is thought to be a chronic immune-mediated disease, but its origin remains elusive, and this limits new therapeutic approaches. Human endogenous retroviruses (HERVs) originate from ancestral infections and represent 8% of the human genome. HERVs are no longer infectious, but some retroviral sequences can be activated, and their aberrant expressions have been implicated in inflammatory and autoimmune disorders. HERV transcription is regulated by TRIM28 and SETDB1, which are also directly involved in epigenetic processes and modulation of the immune response. Using a PCR real-time Taqman amplification assay, we assessed, for the first time, the transcription levels of pol genes of HERV-H, -K, and -W families of env genes of syncytin 1 (SYN1), SYN2, and HERV-W, as well as of TRIM28 and SETDB1 in the whole blood of 48 patients with Crohn’s disease (CD), 20 with ulcerative colitis (UC), and in healthy controls (HC) of comparable age. The transcriptional levels of HERV-H-pol (p = 0.0003) and HERV-K-pol (p = 0.001) were significantly higher in IBD patients compared with HC, with no differences between patients with CD and UC. No significant differences were found for the remaining HERVs between IBD patients and HC. The transcript levels of TRIM28 were significantly downregulated in IBD patients (p < 0.001), without differences between CD and UC, while the SETDB1 levels were preserved. The enhanced transcription of HERV-H-pol and HERV-K-pol, as well as the impaired activation of TRIM28, were not influenced by clinical disease activity and type of treatment. The overexpression of HERVs and impaired transcription of TRIM28 in patients affected by CD or UC suggest that they might be the main actors in the pathophysiology of IBD, opening the way to innovative targeted interventions.

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Diet as an epigenetic factor in inflammatory bowel disease

Cited by 5 publications

References 83 publications

Pro and anti-inflammatory diets as strong epigenetic factors in inflammatory bowel disease

Pro and anti-inflammatory diets as strong epigenetic factors in inflammatory bowel disease

The Impact of a Polyphenol-Rich Supplement on Epigenetic and Cellular Markers of Immune Age: A Pilot Clinical Study

Enhanced Transcription of Human Endogenous Retroviruses and TRIM28 Downregulation in Patients with Inflammatory Bowel Disease

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