Diet and Serum Potassium in Patients on ACE Inhibitors

Good, Chester B.

doi:10.1001/jama.1995.03530070036024

Cited by 11 publications

(3 citation statements)

References 6 publications

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“…ACE inhibitors can cause retention of potassium in the kidney via their inhibitory effect on aldosterone secretion [ 274 , 275 ]. Although the incidence of hyperkalemia associated with ACE inhibitor use in hypertensive patients is 1–2% [ 86 ], two case reports documented older adults consuming high potassium, sodium-restricted diets may be at greater risk of developing hyperkalemia with ACE inhibitor use [ 87 , 88 ]. Additionally, a small retrospective analysis of patients on ACE inhibitors reported the incidence of hyperkalemia to be higher in those with chronic renal failure and diabetes [ 89 ].…”

Section: Part I: Medications Most Likely To Affect Nutritional Stamentioning

confidence: 99%

“…Additionally, a small retrospective analysis of patients on ACE inhibitors reported the incidence of hyperkalemia to be higher in those with chronic renal failure and diabetes [ 89 ]. Others reported the risk of hyperkalemia to be greater in ACE inhibitor patients who have congestive heart failure [ 86 , 90 ], especially if they also consume potassium supplements or potassium-rich foods [ 86 , 91 ]. In a placebo-controlled trial, subjects taking enalapril for 40 months had a three-fold higher rate of hyperkalemia than placebo [ 90 ].…”

Section: Part I: Medications Most Likely To Affect Nutritional Stamentioning

confidence: 99%

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Evidence of Drug–Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update

Mohn

Kern²,

Saltzman

et al. 2018

Pharmaceutics

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The long-term use of prescription and over-the-counter drugs can induce subclinical and clinically relevant micronutrient deficiencies, which may develop gradually over months or even years. Given the large number of medications currently available, the number of research studies examining potential drug–nutrient interactions is quite limited. A comprehensive, updated review of the potential drug–nutrient interactions with chronic use of the most often prescribed medications for commonly diagnosed conditions among the general U.S. adult population is presented. For the majority of the interactions described in this paper, more high-quality intervention trials are needed to better understand their clinical importance and potential consequences. A number of these studies have identified potential risk factors that may make certain populations more susceptible, but guidelines on how to best manage and/or prevent drug-induced nutrient inadequacies are lacking. Although widespread supplementation is not currently recommended, it is important to ensure at-risk patients reach their recommended intakes for vitamins and minerals. In conjunction with an overall healthy diet, appropriate dietary supplementation may be a practical and efficacious way to maintain or improve micronutrient status in patients at risk of deficiencies, such as those taking medications known to compromise nutritional status. The summary evidence presented in this review will help inform future research efforts and, ultimately, guide recommendations for patient care.

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Section: Part I: Medications Most Likely To Affect Nutritional Stamentioning

confidence: 99%

Section: Part I: Medications Most Likely To Affect Nutritional Stamentioning

confidence: 99%

Evidence of Drug–Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update

Mohn

Kern²,

Saltzman

et al. 2018

Pharmaceutics

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show abstract

“…Proline containing molecules display several biological activities. For example Lisinopril, a synthetic peptide derivative, is an oral longacting angiotensin converting enzyme inhibitor [67]. Using a single-mode microwave, a mixture of methionine methyl ester (5 3 ) and 4-fluorobenzaldehyde (5 4 ) in 1,2-dichloroethane was irradiated for 5 min at 180 °C.…”

Section: Pyrrolidinesmentioning

confidence: 99%

Recent Advances in Microwave-Assisted Synthesis of Heterocyclic Compounds

Molteni¹,

Ellis²

2005

COS

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Aellig

1998

Cardiovascular Drugs and Therapy

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A large number of antihypertensive agents are available today. They belong to different drug classes and permit the treating physician to choose the drug he deems best suited for the treatment of an individual patient. Because hypertension is usually asymptomatic yet requires long-term therapy, consideration of potential undesirable effects of drugs used for its treatment is important for making the appropriate choice. In this context, a precise understanding of the typical adverse reaction profiles of the different drugs is essential. This article provides a short review of the adverse reaction profiles of the main classes of antihypertensive drugs and refers to topics such as the recent controversy regarding calcium channel blockers and comparative investigations between different antihypertensive agents. Furthermore, the effects of antihypertensives on metabolic parameters, differences between their effects in subgroups of patients and in patients with different concomitant diseases, and the potential of antihypertensives for interactions with other drugs are briefly discussed. Even with a good knowledge of all of these aspects, however, no fixed plan for drug treatment of hypertension suitable for every patient can be established. A high percentage of adverse drug reactions can, however, be avoided by appropriate drug selection and dosage, carried out after careful consideration of the known adverse reaction profiles as well as the known spectrum of pharmacological actions of the different compounds. Low doses are often effective and well tolerated. Instead of increasing the dose, it is usually preferable to add a low dose of a second agent with a different mode of action if one drug given alone does not sufficiently lower blood pressure. This procedure avoids many adverse drug reactions attributable to an exaggerated pharmacological response, and, if chosen carefully, this combination may also reduce counterregulatory reactions secondary to the fall in blood pressure.

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Diet and Serum Potassium in Patients on ACE Inhibitors

Cited by 11 publications

References 6 publications

Evidence of Drug–Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update

Evidence of Drug–Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update

Recent Advances in Microwave-Assisted Synthesis of Heterocyclic Compounds

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