Diet and Serum Cholesterol in Man Lack of Effect of Dietary Cholesterol ,

Idiopathic Hypercholesterolemia: Demonstration of an Impaired Feedback Control of Cholesterol Synthesis <i>in vivo</i>

“…It has been suggested that the plasma cholesterol level is regulated by an efficient homeostatic mechanism. [1][2][3][4][5] This homeostatic control of the cholesterol concentration in the body has been extensively studied with animal experimenta tions and has been shown to possess the characteristics of a negative feedback control system. [6][7][8][9][10][11] In a recent in vitro study,12 it has been demonstrated that human adults possess a hepatic feedback mechanism for regulating the synthesis of cholesterol.…”

Physical Activity and the Diet in Populations Differing in Serum Cholesterol 1

“…Previously we have reported that samples of men from various populations differ in the average concentration of cholesterol in the blood serum so that, in general, the cholesterol level tends to be directly related to the proportion of the total calories provided by fats in the habitual diet of the population (1)(2)(3)(4)(5)(6). Differences in the cholesterol content of these diets cannot account for the differences in the serum (7).…”

“…In Naples and Malmo, clerical workers, members of the city fire departments and heavy manual workers were studied in parallel from which it appeared that the dietary and not the physical activity characteristic of the group is the major factor in regard to serum cholesterol (5,22). Much new evidence from Bologna, Italy, Sardinia, Minnesota and South Africa, is now at hand to allow a more precise examination of the question.…”

Nutrition and Nutritional Deficiency Diseases

“…doses per day, sitosterol (32,33), a period of weight loss (34), and physical exercise (3S) have been reported to lower cholesterol levels. Cholesterol from exogenous sources raises the blood cholesterol levels of human beings very little and only after a prolonged period of cholesterol feeding (36). Lipotropic agents have little, if any, effect on the blood cholesterol or on the arteriosclerotic process in man (37), but in animals choline deficiency results in arterio sclerosis and fatty liver.…”

“…Though a monkey fed a high (70 per cent) fat diet and 6.51 gm. of cho lesterol per day, for 1388 days developed xanthomas, arteriosclerosis, and very high blood cholesterol levels (62), Keys (36) was not able to demon strate a relationship between dietary cholesterol intake and blood cholesterol levels in human beings.…”