Diet and psoriasis, part III: Role of nutritional supplements

Millsop, Jillian Wong; Bhatia, Bhavnit K.; Debbaneh, Maya; Koo, John; Liao, Wilson

doi:10.1016/j.jaad.2014.03.016

Cited by 79 publications

(96 citation statements)

References 46 publications

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“…It is of great interest to study the impact of diet upon psoriasis [47][48][49]. Curcumin has been known as the "Indian solid gold" since it is an indispensable ingredient used in Indian diet and it has been used in the health care of various human diseases [50].…”

Section: Discussionmentioning

confidence: 99%

The inhibitory mechanism by curcumin on the Zac1-enhanced cyclin D1 expression in human keratinocytes

Hung

Huang

Cheng

et al. 2015

Journal of Dermatological Science

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Section: Discussionmentioning

confidence: 99%

The inhibitory mechanism by curcumin on the Zac1-enhanced cyclin D1 expression in human keratinocytes

Hung

Huang

Cheng

et al. 2015

Journal of Dermatological Science

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“…Association of psoriasis severity and high body mass index (BMI) score has been identified in several recent researches which suggest that bodyweight loss can improve Psoriasis Area and Severity Index score of the patients . In addition, it is certain that healthy eating patterns would benefit psoriatic patients, including the use of oral vitamin B12, vitamin D, selenium and omega‐3 fatty acids in fish oils . As stated earlier, the optimal concentration of vitamin D (25[OH]D) in serum circulating level is 30–50 ng/mL; if obese and lean subjects take the same dose, the circulating level of vitamin D in the obese subject would be insufficient, leaving gradually less 25(OH)D in the organism.…”

Section: Mechanisms Of Environmental Risk Factors’ Impact On Psoriasismentioning

confidence: 99%

Critical role of environmental factors in the pathogenesis of psoriasis

Zeng

Luo

Huang

et al. 2017

The Journal of Dermatology

165

142

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Psoriasis is a common cutaneous disease with multifactorial etiology including genetic and non-genetic factors, such as drugs, smoking, drinking, diet, infection and mental stress. Now, the role of the interaction between environmental factors and genetics are considered to be a main factor in the pathogenesis of psoriasis. However, it is a challenge to explore the mechanisms how the environmental factors break the body balance to affect the onset and development of psoriasis. In this article, we review the pathogenesis of psoriasis and summarize numerous clinical data to reveal the association between environmental factors and psoriasis. In addition, we focus on the mechanisms of environmental risk factors impact on psoriasis and provide a series of potential treatments against environmental risk factors.

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“…A variety of studies have shown that oral vitamin D supplementation and vitamin D analogues have favorable clinical responses and maintain a similar safety profile to topical forms. Although patients did not experience adverse outcomes, the risk of hypercalcemia and bone demineralization is theoretically possible [38][39][40][41]. With the literature support for oral vitamin D, the next step is producing a vitamin D analog that can target the underlying pathophysiology of psoriatic lesions while minimizing adverse effects.…”

Section: Vitamin Dmentioning

confidence: 99%

Psoriasis and Fat-soluble Vitamins: A Review

Usedom¹,

Neidig²,

Allen³

2017

J Clin Exp Dermatol Res

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Fat-soluble vitamins exhibit numerous routes of immune modulation and specifically alter a variety of pathways in psoriasis pathology. Psoriasis, a chronic immune-mediated disease, often requires a combination of topical, oral, and occasionally, subcutaneous or intravenous therapies making disease management complex. With the complexity of treatment, patient adherence is reduced. Vitamin supplementation as an adjunctive treatment would minimize potential adverse effects from systemic medication, increase patient adherence and decrease overall cost. While vitamin A and D are effective topically, oral supplementation is not currently a mainstay of therapy although data exists to support such supplementation. Data on vitamin E and K implicate the significant role each has in the alteration of the inflammatory cascade responsible for psoriasis. Research showing fat-soluble vitamin deficiency in psoriasis exists and presents greater evidence for oral vitamin treatment in addition to first-line therapies. This review presents the mechanism of action in psoriasis of each fat-soluble vitamin and the data on the efficacy of oral fat-soluble vitamin supplementation in psoriasis and systemic inflammation. We also present fat-soluble vitamin deficiency data shown in psoriasis patients. With the evidence of their targeted mechanism of action, efficacy data with oral supplementation, and evidence of deficiency in patients, oral fat-soluble vitamins should be considered as an adjunct to therapy in psoriasis patients.

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Diet and psoriasis, part III: Role of nutritional supplements

Cited by 79 publications

References 46 publications

The inhibitory mechanism by curcumin on the Zac1-enhanced cyclin D1 expression in human keratinocytes

The inhibitory mechanism by curcumin on the Zac1-enhanced cyclin D1 expression in human keratinocytes

Critical role of environmental factors in the pathogenesis of psoriasis

Psoriasis and Fat-soluble Vitamins: A Review

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