Diet and Nutrition in Gynecological Disorders: A Focus on Clinical Studies

Afrin, Sadia; AlAshqar, Abdelrahman; Sabeh, Malak El; Miyashita, Masaki; Reschke, Lauren; Brennan, Joshua T.; Fader, Amanda N.; Borahay, Mostafa A.

doi:10.3390/nu13061747

Cited by 41 publications

(22 citation statements)

References 185 publications

(242 reference statements)

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“…The use of Vitamin D 3 analogues can eliminate the degradation of Vitamin D 3 by tissue 24-hydroxylase, while maintaining the beneficial effects of Vitamin D 3 on UFs [69]. Vitamin D 3 can also promote a healthier composition of the intestinal microbiota, which improves the gut barrier function [123].…”

Section: Discussionmentioning

confidence: 99%

“…A daily diet enriched in fruits and vegetables, which are known sources of carotenoids, quercetin, and indole-3-carbinol, may be one of the simplest and modifiable lifestyle changes with beneficial effects in patients affected by leiomyoma. EGCG and green tea extract may also have applications in the prevention and treatment of UFs [15,94,96,98,123]. A combination of natural substances and vitamins i.e., Vitamin D and EGCG, has been evaluated as useful and effective in reducing fibroid-related symptoms and improving quality of life [88,100].…”

Section: Discussionmentioning

confidence: 99%

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Dietary Natural Compounds and Vitamins as Potential Cofactors in Uterine Fibroids Growth and Development

et al. 2022

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An analysis of the literature generated within the past 20 year-span concerning risks of uterine fibroids (UFs) occurrence and dietary factors was carried out. A link between Vitamin D deficiency and UFs formation is strongly indicated, making it a potent compound in leiomyoma therapy. Analogs of the 25-hydroxyvitamin D3, not susceptible to degradation by tissue 24-hydroxylase, appear to be especially promising and tend to show better therapeutic results. Although research on the role of Vitamin A in the formation of fibroids is contradictory, Vitamin A-enriched diet, as well as synthetic retinoid analogues, may be preventative or limit the growth of fibroids. Unambiguous conclusions cannot be drawn regarding Vitamin E and C supplementation, except for alpha-tocopherol. Alpha-tocopherol as a phytoestrogen taking part in the modulation of estrogen receptors (ERs) involved in UF etiology, should be particularly avoided in therapy. A diet enriched in fruits and vegetables, as sources of carotenoids, polyphenols, quercetin, and indole-3-carbinol, constitutes an easily modifiable lifestyle element with beneficial results in patients with UFs. Other natural substances, such as curcumin, can reduce the oxidative stress and protect against inflammation in leiomyoma. Although the exact effect of probiotics on uterine fibroids has not yet been thoroughly evaluated at this point, the protective role of dairy products, i.e., yogurt consumption, has been indicated. Trace elements such as selenium can also contribute to antioxidative and anti-inflammatory properties of a recommended diet. In contrast, heavy metals, endocrine disrupting chemicals, cigarette smoking, and a diet low in antioxidants and fiber were, alongside genetic predispositions, associated with UFs formation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dietary Natural Compounds and Vitamins as Potential Cofactors in Uterine Fibroids Growth and Development

et al. 2022

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“…The role of dietary modifications and PA has been investigated in women with PCOS; however, this has mainly been researched with a focus on weight reduction and improving IR [ 21 , 23 , 24 , 25 , 26 , 39 ]. It is not yet clear which levels of PA and which concentrations of dietary macronutrients are relevant to androgen or SHBG concentrations.…”

Section: Discussionmentioning

confidence: 99%

“…), the influence of lifestyle factors and macronutrient dietary intake on androgen excess deserves attention. We believe that diet and physical activity could improve PCOS properties not only through weight loss; however, the biological plausibility of these assumptions has not been adequately proven [ 23 , 24 , 25 , 26 , 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Association of Macronutrients Composition, Physical Activity and Serum Androgen Concentration in Young Women with Polycystic Ovary Syndrome

Mizgier¹,

Watrowski

Opydo-Szymaczek

et al. 2021

Nutrients

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The roles of dietary macronutrients and physical activity (PA) in patients with PCOS have not been sufficiently reported, especially in adolescent girls. To address this knowledge gap, we evaluated the associations between serum concentrations of total testosterone (tT), free testosterone (fT), androstenedione (A), dehydroepiandrosterone-sulfate (DHEA-S), sex hormone-binding globulin (SHBG) and dietary macronutrients intake as well as different types and levels of PA. The study population consisted of 96 girls of Caucasian ancestry, aged 14–18 years: 61 participants with polycystic ovary syndrome (PCOS) and 35 healthy controls. Serum tT, fT, A, DHEA-S, and SHBG were determined in fasting blood. Macronutrient intake and PA levels were assessed by using the three-day food record method and the Beliefs and Eating Habits Questionnaire (KomPAN), respectively. We found several positive correlations between dietary macronutrients such as total fat, saturated fatty acids (SFA), monounsaturated (MUFA) and polyunsaturated fatty acids (PUFA), and hormonal parameters across the entire cohort and in healthy girls. A positive correlation between SHBG and total protein consumption as well as an inverse correlation between SHBG and carbohydrate intake could be determined. No correlation between androgens and macronutrients was found in the PCOS group. In contrast, we observed an inverse correlation between androgen concentrations (except of DHEA-S) and “work/school” and/or “leisure time” PA only in PCOS patients. Moreover, the hormone levels differed according to PA intensity. In conclusion, the impact of diet and PA was strikingly different in adolescents with and without PCOS. These findings indicate that disturbed hormonal homeostasis in PCOS, at least in the youngest patients, likely “overtrump” dietary influences, and otherwise, PA offers a therapeutic potential that requires further evaluation of the long-term effects in randomized studies. (ClinicalTrial.gov Identifier: NCT04738409.)

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“…A plethora of systemic and gynecological conditions can affect the female reproductive system and potentially lead to infertility, including polycystic ovarian syndrome (PCOS), endometriosis, premature ovarian failure and pelvic inflammatory disease [4,5]. Besides organic diseases, lifestyle factors such as an unbalanced nutrition and unhealthy diet may interfere with the physiological reproductive functions in women [5,6].…”

Section: Introductionmentioning

confidence: 99%

Dietary Supplements for Female Infertility: A Critical Review of Their Composition

et al. 2021

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Infertility is the condition of about 15% of couples that cannot get a conception after one year of unprotected sexual intercourse. In females, the reduced reproductive capacity underlies the most varied causes. Dietary supplements (DS) might be used to improve the pregnancy rate and a wide range of DS are proposed today to support female fertility. Although many authors demonstrated the positive effect of some of these products, the real efficacy of this approach is still debated. In order to evaluate the potential efficacy of DS for female infertility, we analysed the products marketed in Italy, using an original approach. A review of literature was performed to evaluate the effect of nutraceuticals on various female reproductive outcomes and to detect the minimal effective daily dose (mED) able to improve at least one of these. Thereafter, we conceived a formula to classify the expected efficacy of each DS. Each DS was scored and included into three classes of expected efficacy: higher, lower, and none. Ten out of 24 supplements (41.7%) resulted in the higher and 8 (34.3%) in the lower efficacy group, the remaining 6 DS (25.0%) were expected to have no efficacy. DS marketed in Italy are usually blends of many substances that are frequently employed at a negligible dose or without any evidence of efficacy. These findings raise serious doubt about the potential effectiveness of most commercial DS for female infertility.

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Diet and Nutrition in Gynecological Disorders: A Focus on Clinical Studies

Cited by 41 publications

References 185 publications

Dietary Natural Compounds and Vitamins as Potential Cofactors in Uterine Fibroids Growth and Development

Dietary Natural Compounds and Vitamins as Potential Cofactors in Uterine Fibroids Growth and Development

Association of Macronutrients Composition, Physical Activity and Serum Androgen Concentration in Young Women with Polycystic Ovary Syndrome

Dietary Supplements for Female Infertility: A Critical Review of Their Composition

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