Diet and Metabolism in CKD-Related Metabolic Acidosis

Vincent-Johnson, Anita; Davy, Brenda; Scialla, Julia J.

doi:10.1016/j.semnephrol.2023.151425

Cited by 5 publications

(2 citation statements)

References 95 publications

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“…It is generally progressive and irreversible, affecting multiple metabolic pathways, including acid–base derangements resulting in metabolic acidosis [ 73 ]. Metabolic acidosis, in turn, can lead to muscle wasting, development or exacerbation of bone disease, hypoalbuminemia, increased inflammation, progression of CKD, alterations in insulin, leptin, and growth hormone, and increased mortality [ 80 , 154 ].…”

Section: Dietary Acid Load and Chronic Kidney Diseasementioning

confidence: 99%

“…In comparison, vegetarian/vegan diets with high fruit and vegetable content are often low in acid load and high in potassium bases, which can result in a net alkali load [ 8 , 61 ]. In recent years, the impact of DAL on health and disease has gained increasing recognition [ 20 , 113 , 143 , 154 ]. This narrative review aims to introduce this rapidly developing field, offering a comprehensive overview of its current relationships in health and disease.…”

Section: Introductionmentioning

confidence: 99%

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Dietary acid load in health and disease

Wieërs,

Beynon-Cobb,

Visser

et al. 2024

Pflugers Arch - Eur J Physiol

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Maintaining an appropriate acid–base equilibrium is crucial for human health. A primary influencer of this equilibrium is diet, as foods are metabolized into non-volatile acids or bases. Dietary acid load (DAL) is a measure of the acid load derived from diet, taking into account both the potential renal acid load (PRAL) from food components like protein, potassium, phosphorus, calcium, and magnesium, and the organic acids from foods, which are metabolized to bicarbonate and thus have an alkalinizing effect. Current Western diets are characterized by a high DAL, due to large amounts of animal protein and processed foods. A chronic low-grade metabolic acidosis can occur following a Western diet and is associated with increased morbidity and mortality. Nutritional advice focusing on DAL, rather than macronutrients, is gaining rapid attention as it provides a more holistic approach to managing health. However, current evidence for the role of DAL is mainly associative, and underlying mechanisms are poorly understood. This review focusses on the role of DAL in multiple conditions such as obesity, cardiovascular health, impaired kidney function, and cancer.

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Section: Dietary Acid Load and Chronic Kidney Diseasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dietary acid load in health and disease

Wieërs,

Beynon-Cobb,

Visser

et al. 2024

Pflugers Arch - Eur J Physiol

View full text Add to dashboard Cite

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Introduction: Advances in Nutrition Management in Chronic Kidney Disease

Wang

2023

Seminars in Nephrology

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The potential renal acid load of plant-based meat alternatives

Herter,

Huber,

Storz

2024

Eur J Clin Nutr

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Plant-based meat alternatives (PBMAs) are food products derived from plants and designed to mimic the preparation methods, nutritional profile, and sensorial qualities of meat. PBMAs are currently subject to a controversial debate concerning their health value. Here, we reviewed PBMAs’ potential renal acid load (PRAL). The PRAL is an estimate for the amount of acid or base a certain food produces in the human body, and was associated with tissue damage and acid stress. PRAL values varied substantially across the examined foods, and differences were as large as 19.73 mEq per 100 g of PBMA. Mycoprotein- and wheat-based PBMAs were more acidic than conventional meats. The majority of items, however, exerted a lower PRAL to the human kidneys when compared to their meat-based counterparts. Our findings reiterate that not all PBMAs are created equal, and suggest that PBMAs are generally not suitable to substantially alkalize an individual’s diet.

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Diet and Metabolism in CKD-Related Metabolic Acidosis

Cited by 5 publications

References 95 publications

Dietary acid load in health and disease

Dietary acid load in health and disease

Introduction: Advances in Nutrition Management in Chronic Kidney Disease

The potential renal acid load of plant-based meat alternatives

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