Diet and hair loss: effects of nutrient deficiency and supplement use

Guo, Emily L.; Katta, Rajani

doi:10.5826/dpc.0701a01

Cited by 111 publications

(117 citation statements)

References 62 publications

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“…The strength of the correlation between folic acid concentration and baldness, however, was similar in cases where the age was (Tau = 0.21) and was not (Tau = 0.22) controlled for. In contrast to a general expectation, published data show no empirical evidence for an involvement of folic acid deficiency in alopecia (Almohanna, Ahmed, Tsatalis, & Tosti, 2019; Guo & Katta, 2017). Some studies even seem to support the notion of a positive association between folic acid and alopecia.…”

Section: Discussioncontrasting

confidence: 62%

Increased calcidiol level in redhaired people: Could redheadedness be an adaptation to temperate climate?

Flegr

Sýkorová

Fiala

et al. 2019

Preprint

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About 1-2% of European population are redhaired, meaning they synthesize more 19 pheomelanin than eumelanin, the main melanin pigment. Several mutations could be 20 responsible for this phenotype. It has been suggested that corresponding mutations spread in 21 Europe due to a founder effect shaped either by a relaxation of selection for dark, UV-22 protective phenotypes or by sexual selection in favor of rare phenotypes. In our study, we 23 investigated the levels of vitamin D precursor calcidiol and folic acid in the blood serum of 24 73 redhaired and 130 non-redhaired individuals. In redhaired individuals, we found higher 25 calcidiol concentrations and approximately the same folic acid concentrations as in non-26 redhaired subjects. Calcidiol concentrations correlated with the intensity of hair redness 27 measured by two spectrophotometric methods and estimated by participants themselves and 28 by independent observers. In non-redhaired individuals, calcidiol levels covaried with the 29 amount of sun exposure and intensity of suntan while in redhaired individuals, this was not 30the case. It suggests that increased calcidiol levels in redhaired individuals are due to 31 differences in physiology rather than in behavior. We also found that folic acid levels 32 increased with age and the intensity of baldness and decreased with the frequency of visiting 33 tanning salons. Our results suggest that the redhaired phenotype could be an evolutionary 34 adaptation for sufficient photosynthesis of provitamin D in conditions of low intensity of UV-35 B radiation in central and northern parts of Europe.36

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Section: Discussioncontrasting

confidence: 62%

Increased calcidiol level in redhaired people: Could redheadedness be an adaptation to temperate climate?

Flegr

Sýkorová

Fiala

et al. 2019

Preprint

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“…If warranted, laboratory studies may be obtained. If suspected, evaluation for nutritional deficiency, such as deficiency of iron, zinc, niacin, fatty acids, selenium, vitamins A, D, and E, folic acid, biotin, and amino acids, should ensue …”

Section: Therapeuticsmentioning

confidence: 99%

“…If suspected, evaluation for nutritional deficiency, such as deficiency of iron, zinc, niacin, fatty acids, selenium, vitamins A, D, and E, folic acid, biotin, and amino acids, should ensue. 43 Protecting the scalp from the sun is paramount as ultraviolet radiation contributes to extrinsic aging of hair. Tobacco smoking also carries adverse effects on hair growth.…”

Section: Ther Apeuti C Smentioning

confidence: 99%

The psychological and aesthetic impact of age‐related hair changes in females

Ahluwalia

Fabi

2019

J of Cosmetic Dermatology

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Background While dermatologists focus on practices to promote anti‐aging, thinning hair that frames a more rejuvenated face can affect age perception and cosmesis. Objectives To characterize the effects of age‐related hair changes on age determination and perceived attractiveness. Methods A search was conducted for articles on intrinsic and extrinsic aging as it relates to hair. Key studies on the hair aging process and its effects on self‐perception, confidence, and anti‐aging were reviewed. Results According to several studies, hair density peaks about 27 years of age or earlier and then decreases from the mid‐thirties onward. This serves as an opportunity to prevent or treat hair loss in a similar way we treat aging skin. Without optimizing appearance of hair, overall cosmesis to foster self‐perception can be curtailed despite multiple efforts to rejuvenate and restore the aging face. Conclusion The discrepancy between rejuvenated faces and thinner appearing hair that frames the face highlights the importance of a holistic approach to the anti‐aging consultation. To more comprehensively address the aesthetic patient, we need to promote awareness of the onset of these hair changes in order to incorporate prevention and therapeutic strategies to preserve hair to complement overall appearance.

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“…11 Selenium plays an essential role in oxidative damage protection and hair follicle morphogenesis. 12 Previous experimental studies showed that selenium deficiency tender hair growth. 12 Lacking specific selenoproteins showed oncoming hair loss after birth in knockout mice.…”

Section: Introductionmentioning

confidence: 99%

“…12 Previous experimental studies showed that selenium deficiency tender hair growth. 12 Lacking specific selenoproteins showed oncoming hair loss after birth in knockout mice. 12 Although, there is a lack of human studies, most hair loss supplements in markets contain selenium.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Selenium in Patients with Beta-Thalassemia Major

Jouyban

Chavoshi

et al. 2020

Pharm Sci

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Background: Beta-thalassemia major patients require repeated blood transfusion which is associated with iron overload in different organs such as heart, liver, kidney and their related complications. In this study the effects of selenium in iron overload related complications of patients with beta-thalassemia major were assessed. Methods: In this clinical trial, 34 beta-thalassemia major patients over 12 years old were enrolled. Patients with severe renal failure, history of selenium consumption over the last three months, change of blood transfusion pattern, and any change of chelating agent were excluded from the study. For all patients, tablet of selenium 200 µg/day was administered for a month. Blood samples were taken at baseline and after one-month to assess the level of ferritin, total iron-binding capacity (TIBC), aspartate aminotransferase (AST), alanine aminotransferase (ALT), serum creatinine (Scr), selenium. Hair loss was assessed by questionnaire before and after intervention. Results: From 34 patients, 27 (79.4%) had deficient level of selenium at baseline. The selenium level was increased after intervention (p=0.005). The level of serum ALT and Scr decreased remarkably after one-month selenium consumption (p=0.007 for both). In addition, the AST level decreased remarkably after intervention (p=0.053). Severe hair loss profile has improved significantly after supplementation (p=0.004). Conclusion: One-month selenium consumption improved liver and kidney function related markers remarkably. Moreover, selenium improved hair profile and severe hair loss in thalassemia patients. Further studies are needed on the effect of selenium administration on liver and kidney function.

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Diet and hair loss: effects of nutrient deficiency and supplement use

Cited by 111 publications

References 62 publications

Increased calcidiol level in redhaired people: Could redheadedness be an adaptation to temperate climate?

Increased calcidiol level in redhaired people: Could redheadedness be an adaptation to temperate climate?

The psychological and aesthetic impact of age‐related hair changes in females

Protective Effects of Selenium in Patients with Beta-Thalassemia Major

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