Diet and drinking habits in relation to the development of alcoholic pancreatitis.

Is Obesity an Additional Risk Factor for Alcoholic Chronic Pancreatitis?

“…These data support the hypercaloric/high-fat hypothesis as relevant additional risk factor for ACP, as first postulated by Sarles [24]. The issue has remained controversial in the past [24,25,26,27,28,29,30,31], which is not surprising mainly because of the questionable accuracy of nutritional intake studies by dieticians (retrospectively studied before CP onset). In contrast, overweight, which likely results from hypercaloric food intake, appears a more reliable parameter but this factor was assessed in few studies only [26,38].…”

“…Whether the latter data reflect the maximum BMI before disease onset is unknown, and the relationship between AP and CP according to the ‘necrosis-fibrosis’ hypothesis [1,2,3,22,23] was not taken into account. Therefore, data in the current literature supporting a link between diet and overweight as potential risk factor for ACP are either conflicting [23,24,25,26,27,28,29,30,31] or weak [26,38]. In contrast, we provide first clinical evidence (prospective study) indicating that obesity (due to hypercaloric nutrition) is probably a predisposing risk factor for ACP.…”

“…Third, in the early 60s, Sarles [24] provided evidence that an increased intake of hypercaloric food, particularly fat and proteins, was a risk factor for ACP. Further studies on this issue by other investigators provided controversial results [25,26,27,28,29,30,31]. Surprisingly, data on body weight before disease onset were rarely provided.…”

Acute Pancreatitis is a Chronic Disease

“…The basic pathogenetic mechanism is considered to be the cumulative effect of successive acute insults, or the so-called necrosis-fibrosis sequence, on a background of oxidative stress [8]. In the Western world, the principal causative factor is alcohol [5], although various other effect modifiers such as smoking [9,10], diet [11,12] and genetic predisposition [13][14][15] are thought to play a part in its multifactorial aetiology. Clinical manifestations of chronic pancreatitis, which are variable in extent and time-course, are pain, malabsorption and diabetes.…”

Etiopathogénie des pancréatites chroniques nutritionnelles

“…Ceci (De Caro, Lohse et Sarles, 1979 ;Lohse, Vérine et (Multigner et al, 1983 (Nakagawa et al, 1983 (Kennedi et al, 1985), puis s'atrophie et disparaît (Durbec et Sarles, 1978 Sarles, 1978). Un seul travail contradictoire (Wilson et al, 1985) (Clemente et al, 1984).…”