Diet and Bladder Cancer: A Case–Control Study

Radosavljević, Vladan; Janković, Slavenka; Marinković, Jelena; Dokić, Milan

doi:10.1007/s11255-004-4710-8

Cited by 60 publications

(63 citation statements)

References 24 publications

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“…(GLOBOCAN IARC, 2010) Studies suggest that pork, barbecued meats, fat, butter, soy, eggs and excessive coffee consumption are associated with increased risk (Radosavljevic et al, 2005;Keszei et al, 2010;Silberstein and Parsons, 2010) and vegetables, fruits, and cereal are associated with decreased risk of bladder cancer. Bladder cancer incidence is correlated with SEP (Buntinx et al, 2003), while when adjusted for smoking the relative risk of bladder cancer has been decreased (Goy et al, 2008).…”

Section: 1669 Correlation Of Cancer Incidence With Probable Risk Facmentioning

confidence: 99%

Correlation of Cancer Incidence with Diet, Smoking and Socio-Economic Position Across 22 Districts of Tehran in 2008

Rohani-Rasaf

Abdollahi²,

Jazayeri³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Variation in cancer incidence in geographical locations is due to different lifestyles and risk factors. Diet and socio-economic position (SEP) have been identified as important for the etiology of cancer but patterns are changing and inconsistent. The aim of this study was to investigate correlations of the incidence of common cancers with food groups, total energy, smoking, and SEP. Materials and Methods: In an ecological study, disaggregated cancer data through the National Cancer Registry in Iran (2008) and dietary intake, smoking habits and SEP obtained through a population based survey within the Urban Health Equity Assessment (Urban-HEART) project were correlated across 22 districts of Tehran. Results: Consumption of fruit, meat and dairy products adjusted for energy were positively correlated with bladder, colorectal, prostate and breast and total cancers in men and women, while these cancers were adversely correlated with bread and fat intake. Also prostate, breast, colorectal, bladder and ovarian cancers had a positive correlation with SEP; there was no correlation between SEP and skin cancer in both genders and stomach cancer in men. Conclusions: The incidence of cancer was higher in some regions of Tehran which appeared to be mainly determined by SEP rather than dietary intake. Further individual data are required to investigate reasons of cancer clustering.

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Section: 1669 Correlation Of Cancer Incidence With Probable Risk Facmentioning

confidence: 99%

Correlation of Cancer Incidence with Diet, Smoking and Socio-Economic Position Across 22 Districts of Tehran in 2008

Rohani-Rasaf

Abdollahi²,

Jazayeri³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…5 In Serbia, a significant protective effect was associated with increased urination frequency based on 130 cases and 130 controls in a hospital-based case-control study. 6 This study had a number of limitations, however, including small sample size and minimal information on methods used to determine urination frequency was provided.Our purpose was to evaluate the effect of urination frequency on risk of urothelial (transitional cell) carcinoma of the bladder in a large, multicenter case-control study of bladder cancer. …”

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confidence: 99%

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confidence: 99%

Does increased urination frequency protect against bladder cancer?

Silverman

Alguacil

Rothman

et al. 2008

Intl Journal of Cancer

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Experimental studies suggest that increased urination frequency may reduce bladder cancer risk if carcinogens are present in the urine. Only 2 small studies of the effect of increased urination frequency on bladder cancer risk in humans have been conducted with conflicting results. Our purpose was to evaluate the effect of urination frequency on risk of bladder cancer in a large, multicenter case-control study. We analyzed data based on interviews conducted with 884 patients with newly diagnosed, bladder cancer and 996 controls from 1998 to 2001 in Spain. We observed a consistent, inverse trend in risk with increasing nighttime voiding frequency in both men (p 5 0.0003) and women (p 5 0.07); voiding at least 2 times per night was associated with a significant, 40-50% risk reduction. The protective effect of nocturia was apparent among study participants with low, moderate and high water consumption. The risk associated with cigarette smoking was reduced by nocturia. Compared with nonsmokers who did not urinate at night, current smokers who did not urinate at night had an OR of 7.0 (95% CI 5 4.7-10.2), whereas those who voided at least twice per night had an OR of 3.3 (95% CI 5 1.9-5.8) (p value for trend 5 0.0005). Our findings suggest a strong protective effect of nocturia on bladder cancer risk, providing evidence in humans that bladder cancer risk is related to the contact time of the urothelium with carcinogens in urine. Increased urination frequency, coupled with possible dilution of the urine from increased water intake, may diminish the effect of urinary carcinogens on bladder cancer risk. ' 2008 Wiley-Liss, Inc.Key words: urination frequency; smoking; water intake; bladder neoplasms; epidemiology Experimental evidence suggests that if carcinogens are present in the urine, frequent urination may reduce bladder cancer risk. Three lines of limited evidence support this hypothesis. First, dogs exposed to the bladder carcinogen 2-napthylamine who have undergone surgical diversion of the urine do not develop tumors in the part of the bladder with no urine contact. 1 Second, dogs administered the bladder carcinogen 4-aminobiphenyl and catheterized to regulate urination frequency have decreased levels of urothelial DNA adducts with increased urination frequency. 2 Third, urine appears to be a promoter of bladder carcinogenesis in rat. 3,4 A protective effect of increased urinary frequency is further supported by the results of 2 observational studies. In high-risk areas for bladder cancer in Israel, infrequent micturition and high urine concentration were more prevalent than in low-risk areas. 5 In Serbia, a significant protective effect was associated with increased urination frequency based on 130 cases and 130 controls in a hospital-based case-control study. 6 This study had a number of limitations, however, including small sample size and minimal information on methods used to determine urination frequency was provided.Our purpose was to evaluate the effect of urination frequency on risk of urothelial (tran...

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“…Some authors argued against using total fluid intake and suggest that the daily number of urinary voids is etiologically relevant, because frequency of voiding is directly related to the intensity and duration of urothelium flattening. 40 The few studies 7,41,42 that examined the effect of increased urination frequency on bladder cancer risk found conflicting results. Because volume of fluid intake is strongly correlated with urine volume, 43 we believe that fluid intake and urine volume may be used interchangeably.…”

Section: Discussionmentioning

confidence: 99%

Fluid intake and the risk of urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Ros

Bueno‐de‐Mesquita

Büchner

et al. 2010

Intl Journal of Cancer

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Results from previous studies investigating the association between fluid intake and urothelial cell carcinomas (UCC) are inconsistent. We evaluated this association among 233,236 subjects in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had adequate baseline information on water and total fluid intake. During a mean follow‐up of 9.3 years, 513 first primary UCC occurred. At recruitment, habitual fluid intake was assessed by a food frequency questionnaire. Multivariable hazard ratios were estimated using Cox regression stratified by age, sex and center and adjusted for energy intake, smoking status, duration of smoking and lifetime intensity of smoking. When using the lowest tertile of intake as reference, total fluid intake was not associated with risk of all UCC (HR 1.12; 95%CI 0.86–1.45, p‐trend = 0.42) or with risk of prognostically high‐risk UCC (HR 1.28; 95%CI 0.85–1.93, p‐trend = 0.27) or prognostically low‐risk UCC (HR 0.93; 95%CI 0.65–1.33, p‐trend = 0.74). No associations were observed between risk of UCC and intake of water, coffee, tea and herbal tea and milk and other dairy beverages. For prognostically low‐risk UCC suggestions of an inverse association with alcoholic beverages and of a positive association with soft drinks were seen. Increased risks were found for all UCC and prognostically low‐risk UCC with higher intake of fruit and vegetable juices. In conclusion, total usual fluid intake is not associated with UCC risk in EPIC. The relationships observed for some fluids may be due to chance, but further investigation of the role of all types of fluid is warranted.

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Diet and Bladder Cancer: A Case–Control Study

Cited by 60 publications

References 24 publications

Correlation of Cancer Incidence with Diet, Smoking and Socio-Economic Position Across 22 Districts of Tehran in 2008

Correlation of Cancer Incidence with Diet, Smoking and Socio-Economic Position Across 22 Districts of Tehran in 2008

Does increased urination frequency protect against bladder cancer?

Fluid intake and the risk of urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC)

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