Diet and asthma

Raviv, Stacy; Smith, Lewis J.

doi:10.1097/mcp.0b013e3283323b73

Cited by 17 publications

(11 citation statements)

References 60 publications

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“…It has been suggested that dietary changes may contribute to this increase [9,10,11,12,13]. Flavonoids possess anti-inflammatory, antioxidant, anti-allergic, as well as immune-modulating effects.…”

Section: Discussionmentioning

confidence: 99%

“…It is believed that the interaction between genetic and environmental factors causes individuals to become sensitized to environmental allergens and to suffer from allergic diseases [5,6,7,8]. Since foods and beverages contain both allergy-promoting and anti-allergic nutrients, it has been proposed that dietary change may be one of the environmental factors responsible for such an increase [9,10,11,12,13]. Vitamins A, C, D and E, minerals, such as selenium, copper, zinc and magnesium, probiotics and omega-3 polyunsaturated fatty acids (PUFAs), as well as polyphenols have been shown to possess anti-allergic properties, whereas omega-6 PUFAs are precursors for leukotriene C4, which is known to promote allergic inflammation.…”

Section: Introductionmentioning

confidence: 99%

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Flavonoids and Asthma

Tanaka

Takahashi

2013

Nutrients

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Asthma is a chronic disease, characterized by airway inflammation, airflow limitation, hyper-reactivity and airway remodeling. It is believed that asthma is caused by the interaction between genetic and environmental factors. The prevalence of allergic diseases, including asthma, has increased worldwide during the past two decades. Although the precise reasons that have caused this increase remain unknown, dietary change is thought to be one of the environmental factors. Flavonoids, which are polyphenolic plant secondary metabolites ubiquitously present in vegetables, fruits and beverages, possess antioxidant and anti-allergic traits, as well as immune-modulating activities. Flavonoids are powerful antioxidants and anti-allergic nutrients that inhibit the release of chemical mediators, synthesis of Th2 type cytokines, such as interleukin (IL)-4 and IL-13, and CD40 ligand expression by high-affinity immunoglobulin E (IgE) receptor-expressing cells, such as mast cells and basophils. They also inhibit IL-4-induced signal transduction and affect the differentiation of naïve CD4+ T cells into effector T-cells through their inhibitory effect on the activation of the aryl hydrocarbon receptor. Various studies of flavonoids in asthmatic animal models have demonstrated their beneficial effects. The results of several epidemiological studies suggest that an increase in flavonoid intake is beneficial for asthma. Moreover, clinical trials of flavonoids have shown their ameliorative effects on symptoms related to asthma. However, these human studies are currently limited; further validation is required to clarify whether an appropriate intake of flavonoids may constitute dietary treatment and for part of a preventive strategy for asthma.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Flavonoids and Asthma

Tanaka

Takahashi

2013

Nutrients

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“…Human intervention trials in established asthma have shown some benefit, but overall the results are mixed (2)(3)(4)(5)(6)(7). Although DHA and EPA can be interconverted, these two lipids also exert distinct effects, making the mechanistic interpretation of fish oil interventions difficult.…”

Section: Clinical Relevancementioning

confidence: 96%

Dietary Long-Chain Omega-3 Fatty Acids Do Not Diminish Eosinophilic Pulmonary Inflammation in Mice

Schuster

Bratt

Jiang³

et al. 2014

Am J Respir Cell Mol Biol

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Although the effects of fish oil supplements on airway inflammation in asthma have been studied with varying results, the independent effects of the fish oil components, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), administered separately, are untested. Here, we investigated airway inflammation and hyperresponsiveness using a mouse ovalbumin exposure model of asthma assessing the effects of consuming EPA (1.5% wt/wt), DHA (1.5% wt/wt), EPA plus DHA (0.75% each), or a control diet with no added omega-3 polyunsaturated fatty acids. Consuming these diets for 6 weeks resulted in erythrocyte membrane EPA contents (molar %) of 9.0 (± 0.6), 3.2 (± 0.2), 6.8 (± 0.5), and 0.01 (± 0.0)%; DHA contents were 6.8 (± 0.1), 15.6 (± 0.5), 12.3 (± 0.3), and 3.8 (± 0.2)%, respectively. The DHA group had the highest bronchoalveolar lavage (BAL) fluid eosinophil and IL-6 levels (P < 0.05). Similar trends were seen for macrophages, IL-4, and IL-13, whereas TNF-α was lower in omega-3 polyunsaturated fatty acid groups than the control (P < 0.05). The DHA group also had the highest airway resistance, which differed significantly from the EPA plus DHA group (P < 0.05), which had the lowest. Oxylipins were measured in plasma and BAL fluid, with DHA and EPA suppressing arachidonic acid-derived oxylipin production. DHA-derived oxylipins from the cytochrome P450 and 15-lipoxygenase pathways correlated significantly with BAL eosinophil levels. The proinflammatory effects of DHA suggest that the adverse effects of individual fatty acid formulations should be thoroughly considered before any use as therapeutic agents in asthma.

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“…Although the specific effect of kolaviron,[15] a biflavonoid constituent of G. kola on the airway, is not known with certainty, flavonoids possess antioxidant property that may underlie their effectiveness in asthma. [1617] Flavonoids also impair Ca 2+ release and utilization mechanisms in smooth muscles. [1819] In addition, flavonoids inhibit antigen-induced release of histamine from mast cells, basophils and also inhibit contractions induced by histamine, acetylcholine and phosphodiesterase.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the protective and ameliorative properties of Garcinia kola on histamine-induced bronchoconstriction in guinea pigs

et al. 2012

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Background:Garcinia kola is popularly used in African traditional medicine for the relief of acute bronchoconstrictive episodes.Objective:In this study, we examined the anti-asthmatic and morphological effects of the ethanol extract of G. kola in animal model.Materials and Methods:Guinea pigs were sensitized with ovalbumin and then given doses of 200 or 400 mg/kg/day for 21 consecutive days. Theophylline (10 mg/kg/day) was used as a standard. At the end of the exposure, the animals were exposed to 0.2% histamine aerosol in a chamber. Lymphocyte count, bronchial histology and morphometry were done.Results:Compared with non-sensitized controls, 200 mg/kg/day dose of the extract significantly (P < 0.05) increased the time taken for onset of preconvulsive dyspnea while the dose of 400 mg/kg/day significantly (P < 0.01) reduced bronchial wall thickness. Lymphocytes counts were not significantly affected but the bronchi of extract-treated animals were histologically clearer of lesions visible in the sensitized.Conclusion:These protective and ameliorative properties lend credence to the use of G. kola in ethnomedicine.

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Diet and asthma

Cited by 17 publications

References 60 publications

Flavonoids and Asthma

Flavonoids and Asthma

Dietary Long-Chain Omega-3 Fatty Acids Do Not Diminish Eosinophilic Pulmonary Inflammation in Mice

Evaluation of the protective and ameliorative properties of Garcinia kola on histamine-induced bronchoconstriction in guinea pigs

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