Diesel exhaust exposure impairs recovery of lung epithelial and cellular damage in murine model

Impact of diesel exhaust particles on infections with Mycobacterium bovis BCG in in vitro human macrophages and an in vivo Galleria mellonella model

“…DEPs are described as slightly increasing IL-1β, IL-8, IL-17A, TNF-α and IL-6 levels and decreasing IFN-γ and IL-10, although not in all cases ( Estrella et al, 2019 ; Müller et al, 2021 ). In fact, IL-17A increased expression in the lung is associated with chronic inflammation with neutrophil infiltration and disintegration of the bronchiolar wall ( Singh et al, 2023 ). We have observed a trend in that DEPs reduced the IL-1β, but maybe this discrepancy can be explained by the low concentration of DEPs used, as the higher concentration of DEPs that we used (12.5 μg/ml) increased the production of IL-1β and TNF-α.…”