Diesel exhaust exposure and sirtuins gene expression in old mice

Ribeiro, Gabriel; Costa, Natália; Belotti, Luciano; Alemany, Adair; Cunha, Paula Gabriela da; Duro, Stephanie de Oliveira; Marcourakis, Tânia; Farsky, Sandra Helena Poliselli; Mauad, Thaís

doi:10.1183/1393003.congress-2017.pa381

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unlike SIRT5, the field believes SIRT6 to have antitumor properties through its roles in regulating gene expression, metabolism, and DNA repair. However, these effects can be lost after air pollution exposure, evidenced by an in vivo inhibition of SIRT6 mRNA in the lungs ( Ribeiro et al, 2017 ) As stated earlier, SIRT 6 is proposed as a permanent resident of the nucleus. One outcome is the potential to directly impact DNA repair.…”

Section: Antagonistic Hallmarks Of Aging–mitochondrial Dysfunction De...mentioning

confidence: 97%

Aging, longevity, and the role of environmental stressors: a focus on wildfire smoke and air quality

Scieszka,

Bolt,

McCormick

et al. 2023

Front. Toxicol.

View full text Add to dashboard Cite

Aging is a complex biological process involving multiple interacting mechanisms and is being increasingly linked to environmental exposures such as wildfire smoke. In this review, we detail the hallmarks of aging, emphasizing the role of telomere attrition, cellular senescence, epigenetic alterations, proteostasis, genomic instability, and mitochondrial dysfunction, while also exploring integrative hallmarks - altered intercellular communication and stem cell exhaustion. Within each hallmark of aging, our review explores how environmental disasters like wildfires, and their resultant inhaled toxicants, interact with these aging mechanisms. The intersection between aging and environmental exposures, especially high-concentration insults from wildfires, remains under-studied. Preliminary evidence, from our group and others, suggests that inhaled wildfire smoke can accelerate markers of neurological aging and reduce learning capabilities. This is likely mediated by the augmentation of circulatory factors that compromise vascular and blood-brain barrier integrity, induce chronic neuroinflammation, and promote age-associated proteinopathy-related outcomes. Moreover, wildfire smoke may induce a reduced metabolic, senescent cellular phenotype. Future interventions could potentially leverage combined anti-inflammatory and NAD + boosting compounds to counter these effects. This review underscores the critical need to study the intricate interplay between environmental factors and the biological mechanisms of aging to pave the way for effective interventions.

show abstract

Section: Antagonistic Hallmarks Of Aging–mitochondrial Dysfunction De...mentioning

confidence: 97%