Dielectrophoretic fluidic cell fractionation system

Fifty years of dielectrophoretic cell separation technology

“…This in turn allows for much higher throughput, provided the electrodes are not positioned such that they impede flow. This can be done virtually, by using electrodes above and below the channel to create a volume effect, 41 or physically; 3D electrodes in this manner have been created by the use of electroplating to "grow" electrodes across the channel, 42 or by carbonization of complex pillar shapes formed from the photoresist SU-8. 43 A third approach used vertical traveling-wave dielectrophoresis electrodes, effectively producing a novel field effect for FFF.…”

Towards numerical prototyping of labs-on-chip: modeling for integrated microfluidic devices

“…Copyright 2004 American Institute of Physics with interdigitated electrode arrays. As part of the development of their dielectrophoretic fluidic system for fractionation of biological cells into subpopulations, Li and Kaler (2004) presented numerical simulations of the local electric fields and force profiles. Meinhart et al (2003) presented FEMLAB based simulations of flow induced by combined dielectrophoretic and electrothermal forces (see Green et al (2001) for additional information on electrothermal effects) and achieved quantitative agreement with experimental l-PIV measurements thereby demonstrating the importance of electrothermal forces on particle motion.…”

Blood cell classification utilizing hydrodynamic filtration

“…Separation technologies using microchannels have higher speed and accuracy than macro-scale systems because of the precisely designed/fabricated structures with sizes similar to particles and cells. A number of particle separation methods have been proposed so far, utilizing dielectrophoresis in microchannels [1], isoelectric focusing [2], ultrasonic waves [3], optical tweezers [4], magnetic separation [5], and chromatography.…”