Dielectric properties of mouse MCA1 fibrosarcoma at different stages of development

Swarup, Arvind; Stuchly, S.S.; Surowiec, A.

doi:10.1002/bem.2250120102

Cited by 54 publications

(44 citation statements)

References 12 publications

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“…As a result of this part of study, an electric conductivity of 1.25 S/m was chosen for Sa-1 tumor. This value is five times greater than the conductivity of surrounding connective tissue, which also corresponds to the data in the available literature (24)(25)(26).…”

Section: Materials Properties and Model Verificationsupporting

confidence: 88%

“…The value chosen was five times higher than that of the surrounding connective tissue. Higher conductivity of the tumor tissue is in agreement with available data on tumor conductivity in the literature (24)(25)(26). Electrotherapy was modeled by applying appropriate 1 mundary conditions in correspondence to different electrode configurations previously reported (anodic, cathodic, and "field" electrotherapy) (15).…”

Section: Discussionsupporting

confidence: 77%

See 1 more Smart Citation

Tumor Treatment by Direct Electric Current: Computation of Electric Current and Power Density Distribution

Miklavčič

Šemrov

Valenčic

et al. 1997

Electro- and Magnetobiology

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Electrotherapy by direct electric current was shown to have an antitumor effect in different animal tumor models and in clinic. Information on the current density distributions in the tumor, surrounding tissues, and its differences in the different electrode configurations used in our previous studies could be useful in future studies of electrotherapy mechanisms. Therefore, a three-dimensional, anatomically based, finite element model of the mouse with a subcutaneous tumor was built. Different types of electrotherapy, i.e., different electrode configurations, were modeled by applying appropriate boundaq conditions in the grid points. The magnitude of current density in anodic/cathodic electrotherapy is 50 times higher in the middle and 10 times higher on the edge of the tumor when compared to the "field" electrotherapy. The results of the computation show that the effects of the electrotherapy on tumor growth, which were similar in terms of tumor growth delay in all three configurations, are not directly related to the magnitude of the electric current or power density in the tumor.Address for correseondence: Damijan Miklavcic,

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Section: Materials Properties and Model Verificationsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 77%

Tumor Treatment by Direct Electric Current: Computation of Electric Current and Power Density Distribution

Miklavčič

Šemrov

Valenčic

et al. 1997

Electro- and Magnetobiology

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“…Swarup et al [32] studied the onset of the high values of and in malignant tumors by measuring MCA1 fibrosarcoma mouse tumors at 7, 15, and 30 days after inception. No significant variation of and was seen with tumor age.…”

Section: B Malignant Tumor Propertiesmentioning

confidence: 99%

Two-dimensional FDTD analysis of a pulsed microwave confocal system for breast cancer detection: fixed-focus and antenna-array sensors

Hagness

Taflove²,

Bridges

1998

IEEE Trans. Biomed. Eng.

490

312

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Abstract-A novel focused active microwave system is investigated for detecting tumors in the breast. In contrast to X-ray and ultrasound modalities, the method reviewed here exploits the breast-tissue physical properties unique to the microwave spectrum, namely, the translucent nature of normal breast tissues and the high dielectric contrast between malignant tumors and surrounding lesion-free normal breast tissues. The system uses a pulsed confocal technique and time-gating to enhance the detection of tumors while suppressing the effects of tissue heterogeneity and absorption. Using published data for the dielectric properties of normal breast tissues and malignant tumors, we have conducted a two-dimensional (2-D) finite-difference timedomain (FDTD) computational electromagnetics analysis of the system. The FDTD simulations showed that tumors as small as 2 mm in diameter could be robustly detected in the presence of the background clutter generated by the heterogeneity of the surrounding normal tissue. Lateral spatial resolution of the tumor location was found to be about 0.5 cm.

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“…For example, the average conductivity of the lungs is 0.4 mS/cm during inspiration and 1 mS/cm during expiration-a significant difference. Breast tumors are known to be two to four times more conductive than healthy breast tissue [68,69], and accurate conductivity values are needed to distinguish between benign and malignant lesions.…”

Section: Introductionmentioning

confidence: 99%

Direct Reconstructions of Conductivities from Boundary Measurements

Mueller¹,

Siltanen²

2003

SIAM J. Sci. Comput.

116

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Abstract. The problem of reconstructing an unknown electric conductivity from boundary measurements has applications in medical imaging, geophysics, and nondestructive testing. A. Nachman [Ann. of Math. (2), 143 (1996), pp. 71-96.] proved global uniqueness for the two-dimensional inverse conductivity problem using a constructive method of proof. Based on this proof, Siltanen, Mueller, and Isaacson [Inverse Problems, 16 (2000), pp. 681-699] presented a new numerical reconstruction method that solves the nonlinear problem directly without iteration. The method was verified with nonnoisy rotationally symmetric examples. In this paper the method is extended by introducing a new regularization scheme, which is analyzed theoretically and tested on symmetric and nonsymmetric numerical examples containing computer simulated noise.

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Dielectric properties of mouse MCA1 fibrosarcoma at different stages of development

Cited by 54 publications

References 12 publications

Tumor Treatment by Direct Electric Current: Computation of Electric Current and Power Density Distribution

Tumor Treatment by Direct Electric Current: Computation of Electric Current and Power Density Distribution

Two-dimensional FDTD analysis of a pulsed microwave confocal system for breast cancer detection: fixed-focus and antenna-array sensors

Direct Reconstructions of Conductivities from Boundary Measurements

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