Dielectric characterization of diseased human trabecular bones at microwave frequency

IEEE J. Electromagn. RF Microw. Med. Biol.

Shahzad

Kelly

et al. 2021

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Tissue-Mimicking Mixtures and Anthropomorphic Calcaneus Phantom for Bone Imaging Applications Take-Home Messages• This work presents tissue-mimicking mixtures to mimic the dielectric properties of skin, muscle, cortical bone, and trabecular bone. • Anatomically realistic phantoms must be considered as preclinical testing of the microwave imaging system.• The tissue-mimicking mixtures and the 3D-printed structures presented in this work can be used as a valuable test platform for a microwave imaging system for bone health monitoring. • The recipe of tissue-mimicking mixtures for cortical bone and trabecular bone is presented separately.• This study has proposed separate tissue-mimicking mixtures for cortical bone and trabecular bone.

mentioning

confidence: 99%

Anthropomorphic Calcaneus Phantom for Microwave Bone Imaging Applications

IEEE J. Electromagn. RF Microw. Med. Biol.

Shahzad

Kelly

et al. 2021

Self Cite

“…Besides breast cancer detection, various studies have employed MWI for the diagnosis of brain stroke, exploiting the dielectric contrast between ischemic and healthy tissues [10,11]. Recent studies have investigated the feasibility of using MWI for osteoporosis monitoring [2,12] based on the notable dielectric contrast between healthy and diseased human trabecular bones [13]. The dual-energy X-ray absorptiometry (DXA) is widely employed in clinical practices for bone health monitoring.…”

Section: Introductionmentioning

confidence: 99%

“…Gabriel et al [40] examined the (in vitro) dielectric properties of cortical bone and trabecular bone samples from porcine. This study has developed osteoporotic and osteoarthritis bone phantoms based on single-pole Debye parameters obtained from the dielectric measurements reported by Amin et al [13]. The trabecular bone microarchitecture of osteoarthritis patients is compact and dense compared to osteoporotic patients [41].…”

Section: Introductionmentioning

confidence: 99%

Microwave Bone Imaging: A Preliminary Investigation on Numerical Bone Phantoms for Bone Health Monitoring

Shahzad

O’Halloran

et al. 2020

Sensors

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Microwave tomography (MWT) can be used as an alternative modality for monitoring human bone health. Studies have found a significant dielectric contrast between healthy and diseased human trabecular bones. A set of diverse bone phantoms were developed based on single-pole Debye parameters of osteoporotic and osteoarthritis human trabecular bones. The bone phantoms were designed as a two-layered circular structure, where the outer layer mimics the dielectric properties of the cortical bone and the inner layer mimics the dielectric properties of the trabecular bone. The electromagnetic (EM) inverse scattering problem was solved using a distorted Born iterative method (DBIM). A compressed sensing-based linear inversion approach referred to as iterative method with adaptive thresholding for compressed sensing (IMATCS) has been employed for solving the underdetermined set of linear equations at each DBIM iteration. To overcome the challenges posed by the ill-posedness of the EM inverse scattering problem, the L2-based regularization approach was adopted in the amalgamation of the IMATCS approach. The simulation results showed that osteoporotic and osteoarthritis bones can be differentiated based on the reconstructed dielectric properties even for low values of the signal-to-noise ratio. These results show that the adopted approach can be used to monitor bone health based on the reconstructed dielectric properties.

“…Osteoporosis is one of the major bone disease that results due to loss of minerals from bones and hence leads to bone fragility and fractures [3]. One of our earlier study has found a notable contrast between dielectric properties of healthy and diseased bone samples [12]. Therefore, this dielectric contrast can be exploited by using MWI.…”

Section: Introductionmentioning

confidence: 99%

Microwave bone imaging: experimental evaluation of calcaneus bone phantom and imaging prototype

2020 IEEE MTT-S International Microwave Biomedical Conference (IMBioC)

Sheridan

Kelly

et al. 2020

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Microwave imaging (MWI) can be used as an alternate imaging modality for monitoring bone health. Evaluation and characterization of MWI prototype is a precursor step before in vivo investigation of bone dielectric properties. This paper presents experimental evaluation of a novel two layered simplified cylindrical shaped 3D printed human calcaneus bone phantom along with corresponding MWI prototype designed to image the bone phantom. The shape of the calcaneus bone was approximated with a cylinder. The external and internal layers represent cortical bone and trabecular bone respectively. Each layer of the phantom was filled with respective liquid tissue mimicking mixture (TMM). A MWI prototype was designed having six microstrip antennas in order to hold calcaneus bone phantom. The bone phantom was placed in the imaging prototype and scattered signals were measured at each antenna. Moreover, the performance of the system was explored by examining microwave measurement sensitivity. Based on the measured scattered signals the map of dielectric properties will be constructed by employing MWI algorithm and will be communicated in our future work. This two layered 3D printed human calcaneus bone phantom and imaging prototype can be used as a valuable test platform for pre-clinical assessment of calcaneus bone imaging for monitoring osteoporosis.