Dieckol or phlorofucofuroeckol extracted from Ecklonia cava suppresses lipopolysaccharide-mediated human breast cancer cell migration and invasion

Lee, Young-Ju; Park, Jung Hwan; Park, Sang‐Ah; Joo, Na‐Rae; Lee, Kyung Bok; Oh, Sang‐Muk

doi:10.1007/s10811-019-01899-2

Cited by 19 publications

(10 citation statements)

References 37 publications

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“…In TPA-induced human hepatoma cells, dieckol suppression of MMP-9 occurred via inhibition of the activity of ERK 1/2 and JNK kinases [ 128 ], while in HT1080 cells treated with 6,6’-bieckol both MMP-2 and MMP-9 were suppressed via inhibition of the NF-κB signaling pathway [ 124 ], evidencing the potential role of phlorotannins in inflammation-based tumor development and invasion. Identical findings were reported recently in LPS-stimulated MDA-MB-231 breast cancer cells, in which the treatment either with dieckol or phlorofucofuroeckol A (at 50 and 20 μM, respectively) significantly inhibited the cell migration and invasion via suppression of TLR-4/NF-κB-mediated expression of MMP-9 [ 129 ]. In a different breast cancer cell line (MCF-7 cells), Kim et al [ 127 ] demonstrated that in addition to the inhibition of MMP-9 gene expression, dieckol was also capable stimulate the expression of TIMP-1 and TIMP-2, and even block the expression of VEGF, indicating that this compound may also contribute for the inhibition of tumor vascularization.…”

Section: The Contribution Of Phlorotanninssupporting

confidence: 83%

Brown Algae Phlorotannins: A Marine Alternative to Break the Oxidative Stress, Inflammation and Cancer Network

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et al. 2021

Foods

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According to the WHO, cancer was responsible for an estimated 9.6 million deaths in 2018, making it the second global leading cause of death. The main risk factors that lead to the development of this disease include poor behavioral and dietary habits, such as tobacco use, alcohol use and lack of fruit and vegetable intake, or physical inactivity. In turn, it is well known that polyphenols are deeply implicated with the lower rates of cancer in populations that consume high levels of plant derived foods. In this field, phlorotannins have been under the spotlight in recent years since they have shown exceptional bioactive properties, with great interest for application in food and pharmaceutical industries. Among their multiple bioactive properties, phlorotannins have revealed the capacity to interfere with several biochemical mechanisms that regulate oxidative stress, inflammation and tumorigenesis, which are central aspects in the pathogenesis of cancer. This versatility and ability to act either directly or indirectly at different stages and mechanisms of cancer growth make these compounds highly appealing for the development of new therapeutical strategies to address this world scourge. The present manuscript revises relevant studies focusing the effects of phlorotannins to counteract the oxidative stress–inflammation network, emphasizing their potential for application in cancer prevention and/or treatment.

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Section: The Contribution Of Phlorotanninssupporting

confidence: 83%

Brown Algae Phlorotannins: A Marine Alternative to Break the Oxidative Stress, Inflammation and Cancer Network

Catarino

Amarante

Mateus

et al. 2021

Foods

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“…It was demonstrated that dioxinodehydroeckol, dieckol, and phlorofucofuroeckol, isolated from Ecklonia cava, have anti-proliferative, anti-tumor, anti-inflammatory, anti-adipogenic, and anti-tumorigenic activities. These properties are mainly against breast cancer cell lines MCF-7 and MDA-MB-231, SKOV-3 (ovarian cancer line), HeLa (cervical cancer cell line), HT1080 (fibrosarcoma cancer cell line), A549 (adenocarcinomic human alveolar basal epithelial cell), and HT-29 (human colon cancer cell line) [196][197][198][199][200]. The dieckol demonstrated a high anticancer activity against the non-small-cell lung cancer line A549 [201].…”

Section: Phlorotanninsmentioning

confidence: 99%

Seaweed Phenolics: From Extraction to Applications

et al. 2020

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Seaweeds have attracted high interest in recent years due to their chemical and bioactive properties to find new molecules with valuable applications for humankind. Phenolic compounds are the group of metabolites with the most structural variation and the highest content in seaweeds. The most researched seaweed polyphenol class is the phlorotannins, which are specifically synthesized by brown seaweeds, but there are other polyphenolic compounds, such as bromophenols, flavonoids, phenolic terpenoids, and mycosporine-like amino acids. The compounds already discovered and characterized demonstrate a full range of bioactivities and potential future applications in various industrial sectors. This review focuses on the extraction, purification, and future applications of seaweed phenolic compounds based on the bioactive properties described in the literature. It also intends to provide a comprehensive insight into the phenolic compounds in seaweed.

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“…The latter is shown to be crucial in the development of breast cancer. Moreover, the results indicated that 3 reduced the expression of matrix metalloproteinases (MMPs) 2 and 9, also involved in invasion and metastasis processes [93]. The most recent study carried out by Manandhar et al, investigated the activity of 3, isolated from Ecklonia stolonifera, against a mouse melanoma cell line B16F10.…”

Section: Phlorotanninsmentioning

confidence: 99%

“…Between all phlorotannins, the anticancer properties of dieckol (4) have been the most comprehensively evaluated. Similarly to phlorofucofuroeckol A (3), dieckol (4) also induced a reduction in invasive potential of MCF-7 cells [93]. Zhang and colleagues studied the cytotoxicity of 4, the effect on invasiveness of human fibrosarcoma cells (HT1080) as well as its influence on the expression of MMP-2 and -9.…”

Section: Phlorotanninsmentioning

confidence: 99%

Anticancer Activities of Marine-Derived Phenolic Compounds and Their Derivatives

et al. 2022

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Since the middle of the last century, marine organisms have been identified as producers of chemically and biologically diverse secondary metabolites which have exerted various biological activities including anticancer, anti-inflammatory, antioxidant, antimicrobial, antifouling and others. This review primarily focuses on the marine phenolic compounds and their derivatives with potent anticancer activity, isolated and/or modified in the last decade. Reports on the elucidation of their structures as well as biosynthetic studies and total synthesis are also covered. Presented phenolic compounds inhibited cancer cells proliferation or migration, at sub-micromolar or nanomolar concentrations (lamellarins D (37), M (38), K (39), aspergiolide B (41), fradimycin B (62), makulavamine J (66), mayamycin (69), N-acetyl-N-demethylmayamycin (70) or norhierridin B (75)). In addition, they exhibited anticancer properties by a diverse biological mechanism including induction of apoptosis or inhibition of cell migration and invasive potential. Finally, phlorotannins 1–7 and bromophenols 12–29 represent the most researched phenolic compounds, of which the former are recognized as protective agents against UVB or gamma radiation-induced skin damages. Finally, phenolic metabolites were assorted into six main classes: phlorotannins, bromophenols, flavonoids, coumarins, terpenophenolics, quinones and hydroquinones. The derivatives that could not be attributed to any of the above-mentioned classes were grouped in a separate class named miscellaneous compounds.

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Dieckol or phlorofucofuroeckol extracted from Ecklonia cava suppresses lipopolysaccharide-mediated human breast cancer cell migration and invasion

Cited by 19 publications

References 37 publications

Brown Algae Phlorotannins: A Marine Alternative to Break the Oxidative Stress, Inflammation and Cancer Network

Brown Algae Phlorotannins: A Marine Alternative to Break the Oxidative Stress, Inflammation and Cancer Network

Seaweed Phenolics: From Extraction to Applications

Anticancer Activities of Marine-Derived Phenolic Compounds and Their Derivatives

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