Dieckol, isolated from the edible brown algae Ecklonia cava, induces apoptosis of ovarian cancer cells and inhibits tumor xenograft growth

Ahn, Ji-Hye; Yang, Yeong-In; Lee, Kyung‐Tae; Choi, Jung‐Hye

doi:10.1007/s00432-014-1819-8

Cited by 90 publications

(81 citation statements)

References 69 publications

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“…Moreover, dieckol obstracts the activity of AKT and p38, and overexpression of AKT and p38, at least in part, reversed dieckolinduced apoptosis in SKOV3 cells. These data give the idea that dieckol inhibits ovarian cancer cell growth by inducing caspasedependent apoptosis via ROS production and the regulation of AKT and p38 signaling [50]. Phlorotannin-rich extract from the edible brown alga Ecklonia cava (PREC) combine with cisplatin downregulate the ROS/Akt/NFkB pathways and reduce nephrotoxicity by protecting against normal kidney cell damage [51], (Figure.4).…”

Section: Solieriamentioning

confidence: 97%

“…Different skeletal modifications were performed for better activity. MTT assay shows that modified structure of the cyclo-pentapeptide with an analogous named as A5 remarkably increase in the cytotoxicity and also lowers the IC 50 values than original compound as well as analogues. Western blot and flow Cytometry data reveals that galaxamide or A5 compound flourish apoptosis at 72 hours than early apoptosis through caspase dependent mitochondria mediated activity in HepG2 cell [23].…”

Section: Galax Auramentioning

confidence: 99%

“…U937 HL-60 cells [24] Ecklonia cava A2780, SKOV3 [47][48][49][50][51] Laminaria sp Colon , HeLa, colon Ht-29, HTLV [52,53] Padina sp KB, Hep-2, MCF-7, and SiHa [54] Sargassum sp Hela, MDA MB 231. Dalton's Ascitic lymphoma, HepG2, HT-29, Ca co-2, T47D, MDA-MB468 and /NIH 313, [55][56][57][58][59][60] Stypopodium sp SH-SY5Y, RBL-2H3, (Raw267), (V79), Caco-2.…”

Section: Solieriamentioning

confidence: 99%

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Algae as potential repository of anti cancerous natural compounds

Mridha¹,

Paul²

2017

ijpm

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Algae constitute a promising source of novel compounds with potential as human therapeutic agents. In particular, algae have been considered as a potential source of new bio-active compound. Algae possess several biological activities, including anticancer activity. This review provides a comprehensive report on the several genera of algae belonging to Chlorophyceae, Pheophyceae and Rhodophyceae having anti-proliferative, apoptotic, anti angiogenic as well as cytotoxic efficacy and their mode of action in vitro as well as in vivo condition. Algae are extensively used as functional foods and medicinal herbs, and have a long history of use in Asian countries. Many algae have been used for the treatment of cancer, many crude or partially purified polysaccharides from various brown, green, and red algae have been tested for their antitumor activities. Relevant information was collected from scientific journals, books, and reports via library and electronic search using Medline, Pubmed, Science Direct, and Scopus. The different extracts with some other solvent shows a huge anti-proliferative action on different cancer as well as on different leukemia cell lines. Here we focus on several bioactive compounds that have been derived as well as characterized from different genera of algae and there mechanism of inhibiting cancer cell growth. Considering the ability of the golden treasure present in algae to act against different cancers, this review highlights the potential use of algae as anticancer agents.

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Section: Solieriamentioning

confidence: 97%

Section: Galax Auramentioning

confidence: 99%

Section: Solieriamentioning

confidence: 99%

See 1 more Smart Citation

Algae as potential repository of anti cancerous natural compounds

Mridha¹,

Paul²

2017

ijpm

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show abstract

“…It has rarely been used for food but has been widely utilized in the aquaculture of abalone and seashells. Studies of E. cava have reported its antioxidant (42–46), anti-inflammatory (47–50), anticancer (51,52), and antibacterial (53,54) properties.…”

Section: Introductionmentioning

confidence: 99%

“…E. cava polyphenols exhibit antioxidant (55,56) and anticancer (51,52,59–61) properties as well as contribute to hair growth (57,58). Polyphenol extracts of E. cava have the potential to treat Alzheimer's disease (62) and the polyphenolic extract Seanol affects lipid and glucose metabolism (63).…”

Section: Introductionmentioning

confidence: 99%

Enzyme-treated Ecklonia cava extract inhibits adipogenesis through the downregulation of C/EBPα in 3T3-L1 adipocytes

Kim

Nam

2017

International Journal of Molecular Medicine

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In this study, we examined the inhibitory effects of enzyme-treated Ecklonia cava (EEc) extract on the adipogenesis of 3T3-L1 adipocytes. The components of Ecklonia cava (E. cava) were first separated and purified using the digestive enzymes pectinase (Rapidase® X-Press L) and cellulase (Rohament® CL). We found that the EEc extract contained three distinct phlorotannins: eckol, dieckol and phlorofucofuroeckol-A. Among the phlorotannins, dieckol was the most abundant in the EEc extract at 16 mg/g. Then we examined the inhibitory effects of EEc extract treatment on differentiation-related transcription factors and on adipogenesis-related gene expression in vitro using 3T3-L1 adipocytes. 3T3-L1 pre-adipocytes were used to determine the concentrations of the EEc extract and Garcinia cambogia (Gar) extract that did not result in cytotoxicity. Glucose utilization and triglyceride (TG) accumulation in the EEc-treated adipocytes were similarly inhibited by 50 µg/ml EEc and 200 µg/ml Gar, and these results were confirmed by Oil Red O staining. Protein expression of adipogenesis differentiation-related transcription factors following treatment with the EEc extract was also examined. Only the expression of CCAAT/enhancer-binding protein (C/EBP)α was decreased, while there was no effect on the expression of C/EBPβ, C/EBPδ, and peroxisome proliferator-activated receptor γ (PPARγ). Treatment with the EEc extract decreased the expression levels of adipogenesis-related genes, in particular sterol regulatory element binding protein-1c (SREBP-1c), adipocyte fatty acid binding protein (A-FABP), fatty acid synthase (FAS) and adiponectin. These results suggest that EEc extract treatment has an inhibitory effect on adipogenesis, specifically by affecting the activation of the C/EBPα signaling pathway and the resulting adipogenesis-related gene expression.

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Dieckol inhibits non‐small–cell lung cancer cell proliferation and migration by regulating the PI3K/AKT signaling pathway

Wang

Jin

et al. 2019

J Biochem & Molecular Tox

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Non‐small–cell lung cancer (NSCLC) is one of the most prevalent type of lung cancers with an increased mortality rate in both developed and developing countries worldwide. Dieckol is one such polyphenolic drug extracted from brown algae which has proven antioxidant and anti‐inflammatory properties. In the present study, we evaluated the anticancer property of dieckol against NSCLC cell line A549. The LC50 value of dieckol was found to be 25 µg/mL by performing 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay and the antiapoptotic property of dieckol was analyzed by dual staining technique with acridine orange/propidium iodide (AO/PI) stains. It was further confirmed with flow cytometry analysis with Annexin FITC and JC‐1 staining and the anti‐invasive property was assessed by Transwell assay. The molecular mechanism of dieckol anticancer activity was confirmed by estimating the levels of caspases and by estimating the signaling proteins of Pi3K/AKT/mTOR signaling pathway using the immunoblotting technique. Our data suggest that dieckol is potent anticancer agent, it effectively inhibits the invasive and migratory property A549 cells and it also induces apoptosis via inhibiting Pi3K/AKT/mTOR signaling, activating the tumor suppressor protein E‐cadherin signifying that dieckol is potent natural anticancer drug to treat NSCLC.

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Dieckol, isolated from the edible brown algae Ecklonia cava, induces apoptosis of ovarian cancer cells and inhibits tumor xenograft growth

Abstract: These data suggest that dieckol suppresses ovarian cancer cell growth by inducing caspase-dependent apoptosis via ROS production and the regulation of AKT and p38 signaling.

Cited by 90 publications

References 69 publications

Algae as potential repository of anti cancerous natural compounds

Algae as potential repository of anti cancerous natural compounds

Enzyme-treated Ecklonia cava extract inhibits adipogenesis through the downregulation of C/EBPα in 3T3-L1 adipocytes

Dieckol inhibits non‐small–cell lung cancer cell proliferation and migration by regulating the PI3K/AKT signaling pathway

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