Die Wirkung von Tolbutamid und verwandten Verbindungen auf die Aufnahme von Bromsulphalein (BSP, Bromthalein) durch inkubiertes Lebergewebe

The Transport of Bilirubin in the Circulating Blood and Its Pathogenetic Importance

“…Both nicdicaments occupy the same binding sites on albumin (17, 14, 29, 83, 98), which results in competitive displacenient reactions and in increasing the concentration of free, active tolbutaniid in the blood (23). Conversely in the test of albuniiri-bound bromsulphalein (ESP), tolbutamide accelerates the disappearance of the dye from the blood in the liver, and can therefore in liver tests lead to incorrect diagnosis (38,39). I n addition to this though, tolbutaniide can, through a similar substitution, sink a pathologically in-the endogenous cortisole from its binding to the albumins.…”

Modifications of Albumin Transport Capacity in Pregnant Women and Newborn Infants

“…The competition for the transport surface of plasma albumin leads to the de-adsorption and elimination from the circulating blood of the less strongly bound substances [1,2]. As an example illustrating this we may mention that the administra tion of tolbutamine accelerates the disappearance of bromsulphalein from the blood and therefore in liver tests it can lead to incorrect dia gnosis [14,15]. The binding of transport material to plasma proteins makes the passage of bound substances through the blood-brain and blood-liquor barrier more difficult.…”