Die Wirkung von synthetischem Hypertensin II auf die Pah-und Inulin-Clearance, die renale H�modynamik dnd die Diurese beim Menschen

Prolonged Infusions of Angiotensin II and Norepinephrine and Blood Pressure, Electrolyte Balance, and Aldosterone and Cortisol Secretion in Normal Man and in Cirrhosis with Ascites*

“…This mechanism implies that increases of circulating levels of angiotensin and elevations of systemic blood pressure have opposing effects on renal sodium excretion. The sodium-retaining effect of lower doses of angiotensin has been repeatedly demonstrated (25)(26)(27). Also, elevations of arterial pressure per se can promote natriuresis in normal animals, (4648) and more specifically in patients with cirrhosis and ascites (25,49).…”

“…Pressure rises from angiotensin or norepinephrine have not heretofore been related to cerebral bleeding in extensive studies of animals and man. Throughout this study the infusion rate was 1.5 ,ug per minute, a rate well below that employed in other reports (26)(27)(28)(29)(30)(31)(32)(33)(34). Because of this occurrence, this study and all other investigations with infusions of pressor agents were terminated immediately.…”

Effect of Aldostetone and Salt Intake on Renal and Pressor Actions of Angiotensin

“…Natriuresis in these studies may sometimes be due to the use of larger doses of angiotensin than in normals (19). Further, whereas in normal man, GFR falls considerably during angiotensin infusion (1,2,9,21), it falls much less in response to angiotensin in states of hyperaldosteronism (3,19), which could allow any natriuretic effect to be more apparent. Similarly, in the study which reported aug mentation of natriuresis with angiotensin in dogs with ascites as op posed to normals (24), GFR actually increased by 3.8% in the former group during angiotensin but was not significantly affected in the latter.…”

Loss of the Renal Vasoconstrictor Activity of Angiotensin II during Renal Ischemia*

“…Tachyphylaxis to the vascular effects of small to moderate amounts of angiotensin II administered by prolonged intravenous infusion (16) or repeated injections (17) in unanesthetized dogs has not been demonstrated. However, tachyphylaxis expressed by a change in the pressor response (17) or the glomerular filtration rate and renal plasma flow (18) to angiotensin II in high doses has been reported. In secondary hyperaldosteronism, a tachyphylaxis to angiotensin II, even in small amounts, has been suggested to explain the reduced vascular sensitivity to injected angiotensin II (19).…”