Die Wirkung von Physostigmin und Oximen auf die pr�ganglion�ren Aktionspotentiale des N. sympathicus an Ratten

Nakagawa, Atsushi

doi:10.1007/bf00536769

Cited by 6 publications

(1 citation statement)

References 9 publications

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“…This irreversible cholinesterase inhibitor will reduce enzyme activity for much longer than physostigmine, the pressor effects of which were reported to be short-lasting (e.g. Nakagawa, 1968). Moreover, the effects by physostigmine cannot be attributed to inhibition of cholinesterase only (Cox & Lomas, 1972;Bartolini, Bartolini & Domino, 1973).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Paraoxon on Blood Pressure in the Anaesthetized and in the Conscious Rat

Neef

Jordaan

Porsius

1982

British J Pharmacology

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1Intravenous administration of paraoxon tLg/kg) to anaesthetized rats induced longlasting, dose-dependent pressor effects. Only after injection of 825 jig/kg paraoxon was the pressor response followed by a depressor effect and a bradycardia that could be blocked by Nmethylatropine. Intracerebroventricular injection of paraoxon into anaesthetized rats also induced pressor effects. 2 In order to elucidate the mechanism of the pressor action rats were given dexetimide, Nmethylatropine, mecamylamine, phentolamine, prazosin, yohimbine, atenolol and metoprolol. If treatment with these drugs resulted in a low initial blood pressure, vasopressin was infused to elevate blood pressure to normal levels. The influence of adrenalectomy, pretreatment with reserpine and midcollicular transection was also examined. 3 The pressor effect of paraoxon was not influenced by N-methylatropine or mecamylamine. However, a combination of these drugs as well as dexetimide, phentolamine or prazosin combined with yohimbine, reduced or prevented the pressor effect. 4 In conscious rats the effects of paraoxon and the action of antimuscarinic drugs upon the pressor response were similar to those observed in anaesthetized animals. 5Acetylcholinesterase activities were measured in various brain regions and in whole blood. Paraoxon concentrations within the CNS were also measured. 6 It is concluded that the pressor effect of paraoxon in anaesthetized and conscious rats is mediated by a central mechanism, although a contribution of peripheral acetylcholinesterase inhibition in sympathetic ganglia to this pressor effect cannot be ruled out.

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Section: Introductionmentioning

confidence: 99%