Die wirkung von phenylbutazon und phenobarbital auf die amidopyrin-elimination, die bilirubin-gesamtkonzentration im serum und einige blutgerinnungsfaktoren bei neugeborenen kindern

Developmental Aspects of the Hepatic Cytochrome P450 Monooxygenase System

“…Notably, the elimination rates of other compounds that undergo metabolic oxidation, but do not exhibit saturation kinetics at therapeu tic concentrations in adults, can change similarly in the neonatal period. These agents include phenobarbital (see below), tolbutamide (161), and aminopyrine (162). Other drugs have displayed slow rates of elimination in the early postnatal period, but the time at which rates increase is less clearly defined; these include acetanilid (163), diazepam (139,(164)(165)(166), amobarbital (167), nortriptylene (168), and mepivacaine (169).…”

Diazepam elimination in premature and full term infants, and children

“…For this reason studies and observations on newborn infants provide further useful Information, which can eventually be applied to everyday practice. Most of the data currently available on drug kinetics and metabolism in the newborn infant concern antibiotic and sulfonamide compounds [8,11,23,24,26,27,28] though some observations have also been carried out with other drugs [13,14,21,22,30,31]. In most cases they indicate a slower disposition of the drug äs compared to children.…”

Human Growth

“…The plasma disappearance of the drug shows an inverse correlation to the appearance of the oxidized metabolite, carboxytolbutamine, in the urine. Further proof of decreased oxidative ability was gathered when aminopyrine half-life was shown to decrease from the first to the 8-day of life in normal full-term infants (Reinicke et al, 1970). A functional deficiency in reduction mechanisms was suggested by the observation that a decreased ratio of conjugated:free compounds follows the exogenous administration of cortisol to the neonate.…”