Die Wirkung von Fols�ureantagonisten (Methotrexat) auf die Regeneration der Darmschleimhaut

Eder, M.; Rostock, H.; Vogel, G

doi:10.1007/bf00958980

Cited by 17 publications

(4 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…W hatever the drug used and its pharmacological effect, w hether folic acid inhibitors (m ethotrexate or am inopterin) [4,5,6,15,18,22,23,25], fluorinated pyrim idin (5 Fluorouracil) [9,14,17], the overall results are sim ilar.…”

Section: Discussionmentioning

confidence: 88%

Correlation Between the Histological Changes and Glucose Intestinal Absorption Following a Single Dose of 5 Fluorouracil

Ac¹,

Jc²,

Bognel³

et al. 1970

Digestion

View full text Add to dashboard Cite

The effect of an antimitotic drug on the digestive tract was studied in the rat’s small intestine perfused in vivo with solutions of varying glucose concentrations. The histological changes of the intestinal mucosa are correlated with the absorptive capacity for glucose. A reduction in cell population followed injection of 5 Fluorouracil; there is a linear correlation between the number of epithelial cells and the height of villous processus. The quantity of glucose absorbed is reduced during the intoxication, and is linked to the number of cells. The study of absorption kinetics shows a linear correlation between the maximal rate of absorption (Vmax) and the number of cells, but the Km is only modified during the period of maximum intoxication showing a cytotoxicity.

show abstract

Section: Discussionmentioning

confidence: 88%

Correlation Between the Histological Changes and Glucose Intestinal Absorption Following a Single Dose of 5 Fluorouracil

Ac¹,

Jc²,

Bognel³

et al. 1970

Digestion

View full text Add to dashboard Cite

show abstract

“…The decrease in villus height and villus cell count is also consistant with the results after a single dose of various cytostatics (3,9,30,38,39). The tendency of the villi in GF rats to become smaller at an earlier stage than in the SPF rats cannot be explained satisfactorily.…”

Section: Discussionmentioning

confidence: 85%

“…The decrease in crypt depth, crypt cell count and mitotic frequency reflects the damage to the regenerative cell population and is described after a single high dose of various cytostatics (3,9,30,33,39). The decrease in villus height and villus cell count is also consistant with the results after a single dose of various cytostatics (3,9,30,38,39).…”

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

The Effect of a Single Dose of Cyclophosphamide on the Jejunum of Specified Pathogenfree and Germfree Rats

Ecknauer¹,

Löhrs²

1976

Digestion

View full text Add to dashboard Cite

After a single dose of cyclophosphamide (100 mg/kg) cell proliferation in the jejunum of the rat decreased within the first 24 h and returned to the initial level after 48 h. Under the influence of cyclophosphamide, an increased cell loss in germfree rats could be observed. Villus height and villus cell count tended to decrease. Changes in disaccharidase activity in mucosal scrapings with respect to protein and DNA content could not be demonstrated. An influence of presence or absence of bacterial flora could be observed.

show abstract

Cytochemistry of the Human Jejunal Mucosa in the Norm and in Malabsorption Syndrome

Lojda¹,

Frič²,

Jodl³

et al. 1970

Current Topics in Pathology

View full text Add to dashboard Cite

Die Wirkung von Fols�ureantagonisten (Methotrexat) auf die Regeneration der Darmschleimhaut

Cited by 17 publications

References 8 publications

Correlation Between the Histological Changes and Glucose Intestinal Absorption Following a Single Dose of 5 Fluorouracil

Correlation Between the Histological Changes and Glucose Intestinal Absorption Following a Single Dose of 5 Fluorouracil

The Effect of a Single Dose of Cyclophosphamide on the Jejunum of Specified Pathogenfree and Germfree Rats

Cytochemistry of the Human Jejunal Mucosa in the Norm and in Malabsorption Syndrome

Contact Info

Product

Resources

About