Die Wirkung von 2,6-Bis (diäthanolamino)-4,8-dipiperidino-pyrimido (5,4-d)pyrimidin auf die Durchblutung des experimentellen Herzinfarkts und des gesunden Herzmuskels

Kiese, Manfred; Lange, G.; Resag, K.

doi:10.1007/bf02045659

Cited by 25 publications

(4 citation statements)

References 2 publications

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“…However, in the latter situation, increased flow may merely be going to myocardial regions fed by normal vessels rather than areas supplied by obstructed vessels. While some investigators have found that vasodilators increase flow to compromised myocardium (2)(3)(4)(5)(6)(7)(8), others have found a decrease or no change (9)(10)(11)(12)(13)(14). Fam and McGregor (11) have pointed out that these discrepancies may be related in part to differences in action among the various coronary dilators.…”

Section: Introductionmentioning

confidence: 99%

Effect of nitroglycerin and dipyridamole on regional left ventricular blood flow during coronary artery occlusion.

Becker

1976

J. Clin. Invest.

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A B S T R A C T Coronary vasodilators have been vari-ously reported to increase, decrease, or have no effect upon blood flow to ischemic myocardium. Consequently, the effects of two different types of dilators, nitroglycerin (TNG) and dipyridamole, were studied with radioactive microspheres in open-chested dogs after coronary artery ligation. Given as a bolus i.v. injection, 0.4 mg TNG resulted in an increase in blood flow to nonischemic areas of myocardium and a preservation of flow to ischemic regions, despite a fall in blood pressure. 5 min later blood pressure and nonischemic flow were back to base line, and a small selective increase in flow to ischemic myocardium was found (0.15-0.18 ml/min per g, P < 0.05). During an 0.2 mg/min infusion of TNG, and also after 1 mg/kg i.v. dipyridamole, ischemic flow was maintained in the face of a 20-30%o reduction in blood pressure. In this setting, nonischemic flow was unchanged during TNG and doubled after dipyridamole. With the addition of methoxamine in both dilator groups, blood pressure retumed to base line while flow to ischemic areas increased above base-line values (TNG, 0.16-0.20 ml/min per g, P < 0.01; dipyridamole, 0.18-0.31 ml/min per g, P < 0.05). Epicardial ST segment elevations increased during TNG infusion and were unchanged after dipyridamole, but with addition of methoxamine, ST segments became less elevated in both drug groups, concomitant with the observed increase in collateral blood flow. These data indicate thaA both types of coronary vasodilators, when used in conjunction with methoxamine to support blood pressure, reduce collateral resistance, increase collateral flow, and reduce epicardial ST-segment elevations.

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Section: Introductionmentioning

confidence: 99%

Effect of nitroglycerin and dipyridamole on regional left ventricular blood flow during coronary artery occlusion.

Becker

1976

J. Clin. Invest.

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“…Using a heat clearance technique a number of authors (Kiese, Lange & Resag, 1960;Lange, 1964;Kadatz, 1969;Grayson et al, 1971) have demonstrated that dipyridamole increases flow in experimental infarcts in dogs. This flow change is rather less than that which occurs in normal cardiac muscle.…”

Section: Introductionmentioning

confidence: 99%

“…Of the increasing number of coronary vasodilator drugs available most experimental work has been done with dipyridamole (for references and a recent summary of activity see Parratt, 1969). Using a heat clearance technique a number of authors (Kiese, Lange & Resag, 1960;Lange, 1964;Kadatz, 1969;Grayson et al, 1971) have demonstrated that dipyridamole increases flow in experimental infarcts in dogs. This flow change is rather less than that which occurs in normal cardiac muscle.…”

Section: Introductionmentioning

confidence: 99%

The effects of dipyridamole on blood flow and oxygen handling in the acutely ischaemic and normal canine myocardium

Marshall

Parratt

1973

British J Pharmacology

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Summary1. The effects of the intravenous administration of dipyridamole (0 25 mg/kg) were examined in a canine preparation that enabled simultaneous measurements to be made of blood flow in ischaemic and in essentially normal areas of the myocardium and also of oxygen handling (availability, consumption and extraction) in both these regions. 2. When administered to dogs anaesthetized with trichlorethylene 2-3 h after acute ligation of the descending branch of the left coronary artery, dipyridamole markedly increased blood flow in essentially normal regions (left circumflex flow) but failed to increase flow in the area supplied by the ligated vessel (measured by "xenon clearance and by retrograde flow). In five of the six animals definite decreases in flow ('stealing') were observed in the ischaemic region. These flow changes were related to the decreased trans-ventricular perfusion pressure (diastolic peripheral coronary pressure minus left ventricular end-diastolic pressure) and were accompanied by electrocardiographic evidence of increasingly severe myocardial ischaemia. The results support the suggestion that only increasing the perfusion gradient will usefully improve blood flow (and hence oxygen availability) to the acutely ischaemic myocardium. 3. Despite these effects on ischaemic muscle blood flow, the oxygen tension of the blood draining the infarcting muscle was markedly elevated. The conclusion is drawn that dipyridamole decreases the efficiency of the myocardial circulation by opening up vessels that do not take part in tissue exchange.

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“…If this were the case, this might be expected to lead to a reduction in myocardial contractility. However, many investigators report that dipyridamole has no inotropic effect (Kiese, Lange & Resag, 1960;West, Bellet, Manzoli & Muller, 1962), whereas others report increased contractility (Elliot, 1961;Yu & Gluckman, 1969). The most probable conclusion therefore is that dipyridamole, directly or indirectly, leads to increased efficiency of utilization of free energy by the contractile mechanisms.…”

Section: Discussionmentioning

confidence: 99%

The Action of Nitroglycerine and Dipyridamole in Normal and Ischaemic Dog Heart

Grayson

Scott

1975

British J Pharmacology

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Network and post‐network resistances were measured together with heat clearance and heat production in the myocardium. Nitroglycerine dilated all resistance vessels but was twice as effective on network as compared with post‐network vessels. Dipyridamole dilated network and post‐network vessels equally. Nitroglycerine had no effect on heat clearance or heat production in ischaemic myocardium. Dipyridamole increased heat clearance in normal but not in ischaemic myocardium. Dipyridamole depressed heat production in normal and ischaemic myocardium. That the clinical effectiveness of nitroglycerine does not depend entirely on its coronary vasodilator properties is confirmed. It is suggested that the action of dipyridamole in depressing myocardial heat production may be due to an action on the efficiency of oxygen utilization during cardiac contraction.

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Die Wirkung von 2,6-Bis (diäthanolamino)-4,8-dipiperidino-pyrimido (5,4-d)pyrimidin auf die Durchblutung des experimentellen Herzinfarkts und des gesunden Herzmuskels

Cited by 25 publications

References 2 publications

Effect of nitroglycerin and dipyridamole on regional left ventricular blood flow during coronary artery occlusion.

Effect of nitroglycerin and dipyridamole on regional left ventricular blood flow during coronary artery occlusion.

The effects of dipyridamole on blood flow and oxygen handling in the acutely ischaemic and normal canine myocardium

The Action of Nitroglycerine and Dipyridamole in Normal and Ischaemic Dog Heart

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