Die Wirkung verschiedener Substanzen auf die �berlebenszeit von Kaninchen unter Sauerstoffmangelbedingungen

Abstract

In 30 rabbits, which had accidentally been divided into five groups of different treatment the effect of the substance Persantin, Actihaemyl and Noleptan was investigated in view of the time of survival of the animals and the behaviour of the acid-base-balance and the blood-gases under conditions of oxygen-delay. There were two control-groups. One collective was treated with Haemaccel, the other with Glucose. In those groups treated with Persantin, Actihaemyl and Noleptan the time of survival of the animals is significantly higher in comparison with the animals of the control-groups. The behaviour of the acid-base-balance and the blood-gases in the collective treated with Persantin points to a reduction of the dimension of the metabolic acidosis. This effect cannot be assumed for Actihaemyl because of this investigation. The effect of Noleptan seems to depend on an improvement of the gas exchange in the lungs of the rabbits. The results of this investigation show that the application of Persantin and Actihaemyl might be an interesting enrichment of the medicamental treatment of the intrauterine acidoses.