Die Wirkung des Reserpins auf den Hormongehalt des Nebennierenmarks

Kroneberg, G.; Hj, Schümann

doi:10.1007/bf00246937

Cited by 54 publications

(8 citation statements)

References 6 publications

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“…The total catechol amine content of the adrenal glands was reduced to a slight but just significant extent. Reserpine, however, depleted mouse adrenal glands of catechol amines by only 30%, even though it reduced brain levels by over 90% and has been shown to reduce the adrenal catechol amines more markedly in other species (Kroneberg & Schumann, 1957).…”

Section: Discussionmentioning

confidence: 96%

The Increase in the Toxicity of Yohimbine Induced by Imipramine and Other Drugs in Mice

Quinton

1963

British Journal of Pharmacology and Chemotherapy

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In mice, yohimbine appears to accentuate the normal " alarm " reactions (alerting, flight) to external stimuli. Imipramine increases this effect and at the same time converts a non-lethal dose of yohimbine into a lethal one. The effect of imipramine is greatly reduced by adrenalectomy or by treatment with reserpine, syrosingopine, ganglion-blocking drugs or adrenaline antagonists acting on sympathetic 3-receptors. Hypnotic, anti-convulsant or anaesthetic agents, tetrabenazine or antagonists of 5-hydroxytryptamine do not reduce the imipramine effect. A variety of drugs which, like imipramine, are known to interfere with the tissue binding of noradrenaline also increase the toxicity of yohimbine. Yohimbine significantly reduces brain noradrenaline content; adrenal catechol amines are slightly reduced. The results suggest that yohimbine releases noradrenaline from stores or nerves as a consequence of increased central sympathetic activity. Imipramine increases the actions and toxicity of yohimbine by increasing the effects of the released noradrenaline on 1-receptors.The lethal effects of a high dose of yohimbine alone are not reduced by any of the treatments tested, and appear not to result from activation of sympathetic mechanisms.

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Section: Discussionmentioning

confidence: 96%

The Increase in the Toxicity of Yohimbine Induced by Imipramine and Other Drugs in Mice

Quinton

1963

British Journal of Pharmacology and Chemotherapy

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“…However, Coupland (1958b), studying the depletion of the amines in transplants of adrenal medullary tissue in the eye of the rat, found that 48 hr instead of 24 hr were needed to reach maximal depletion. Kroneberg & Schumann (1957b) could not demonstrate any protection against 10 mg/kg of reserpine even after section of the spinal cord at the level of the sixth cervical segment. Mirkin (1958) also did not find any difference between innervated and denervated glands following treatment with 5 daily doses of 1 mg/kg of reserpine injected intraperitoneally.…”

Section: Re-depletion Experimentsmentioning

confidence: 70%

“…They also showed that the relative proportions of adrenaline and noradrenaline were normal even in glands still partially depleted at 8 to 9 days. Kroneberg & Schumann (1957b) found that depletion of rat adrenal glands by doses of 10 mg/kg of reserpine could not be prevented by section of the spinal cord at the level of the sixth cervical segment. Mirkin (1958) could not demonstrate any difference in the response of innervated and denervated rat adrenal glands to 5 daily intraperitoneal injections of 1 mg/kg of reserpine.…”

mentioning

confidence: 96%

Depletion and Replacement of the Adrenaline and Noradrenaline Contents of the Rat Adrenal Gland, Following Treatment With Reserpine

Callingham¹,

Mann²

1962

British Journal of Pharmacology and Chemotherapy

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The effect of reserpine on the adrenaline and noradrenaline contents of rat adrenal glands has been studied. Given subcutaneously to male albino Wistar rats in 3 daily doses of 1 mg/kg, it caused, 24 hr after the final dose, a similar percentage loss of adrenaline and noradrenaline of approximately 50%. Subsequently the adrenaline content slowly increased, until at 14 days from the begining of the experiment there was no significant difference between the reserpine-treated and the control glands. In contrast, the recovery of the noradrenaline content was rapid, exceeding the control value at 7 days by approximately 250%. This increased content of noradrenaline declined to the normal level by 21 days. The total amine content returned to normal by 7 days and remained at this level subsequently. The effect of re-depleting the glands of their amine content was investigated. It was found that re-depletion at 7 days caused a preferential release of noradrenaline, followed at 14 days by a peak of noradrenaline at least as high as that obtained following the initial depletion only. Re-depletion at 21 days caused an effect similar to that obtained initially. Denervation of the left adrenal gland did not alter the degree of depletion caused by reserpine, nor did it alter the subsequent replacement of the amines as compared with that in the innervated right gland.In 1956 Holzbauer & Vogt showed that reserpine caused a loss of adrenaline and noradrenaline from the adrenal gland of the cat. Carlsson & Hillarp (1956) demonstrated a similar effect in the rabbit adrenal gland, and Parratt & West (1957) noted that the adrenal gland of the rat was markedly depleted by doses of 10 mg/kg of reserpine. Taketomo, Shore, Tomich, Kuntzman & Brodie (1957) found that, following depletion of the rabbit adrenal gland, 5 to 7 days were necessary for the amine stores to be replenished and that the depletion could be prevented by section of the spinal cord at the level of the first thoracic segment. Kroneberg & Schumann (1957a) also demonstrated that recovery was slow and that cutting the splanchnic nerves one week previously only partially protected the glands from depletion. Muscholl & Vogt (1958) found that 14 days were necessary for replacement of the catechol amine content of the rabbit adrenal medulla following depletion by a single intravenous dose of 1.6 mg/kg of reserpine. They also showed that the relative proportions of adrenaline and noradrenaline were normal even in glands still partially depleted at 8 to 9 days.

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“…However, in the rat, depletion of adrenal catecholamines by reserpine is not affected by splanchnic nerve section (MIRKIN, 1958;CALLINGHAM and MANN, 1962) or by spinal section at C6 (KRONEBERG and SCHUMANN, 1957b). It was suggested that reserpine may act centrally in small doses to cause depletion of the adrenal catecholamines, but large doses have a more direct peripheral action which overshadows any central effect; most studies in the rat have been concerned with the latter effect (CALLINGHAM and MANN, 1962).…”

Section: Adrenal Medullary Aminesmentioning

confidence: 96%