Die Virushepatitiden A bis E: Prävalenz, Erregermerkmale und Pathogenese

Bender, Daniela; Glitscher, Mirco; Hildt, Eberhard

doi:10.1007/s00103-021-03472-0

Cited by 5 publications

(3 citation statements)

References 48 publications

(76 reference statements)

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“…Middle-aged and older adult people have poorer immunity and are more susceptible to illness after being infected. Infection usually presents apparent infection in adults and subclinical or silent infection in children and adolescents ( 38 ). HE in Jiangsu province is mainly a zoonotic disease.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the spatial-temporal distribution characteristics of hepatitis E in Jiangsu province from 2005 to 2020

Shi,

Shen,

Liu

et al. 2023

Front. Public Health

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ObjectiveThis study attempts to analyze the spatial clustering and spatial-temporal distribution characteristics of hepatitis E (HE) at the county (city and district) level in Jiangsu province to provide a scientific basis for the prevention and control of HE.MethodThe information on HE cases reported in the Chinese Center for Disease Control and Prevention Information System from 2005 to 2020 was collected for spatial autocorrelation analysis and spatial-temporal clustering analysis.ResultFrom 2005 to 2020, 48,456 HE cases were reported in Jiangsu province, with an average annual incidence rate of 3.87/100,000. Male cases outnumbered female cases (2.46:1), and the incidence was highest in the 30–70 years of age group (80.50%). Farmers accounted for more than half of all cases (59.86%), and in terms of the average annual incidence, the top three cities were all in Zhenjiang city. Spatial autocorrelation analysis showed that Global Moran's I of HE incidence varied from 0.232 to 0.513 for the years. From 2005 to 2020, 31 counties (cities and districts) had high and statistically significant HE incidence, and two clustering areas were detected by spatial-temporal scanning.ConclusionHE incidence in Jiangsu province from 2005 to 2020 was stable, with age and gender differences, regional clustering, and spatial-temporal clustering. Further investigation of HE clustering areas is necessary to formulate corresponding targeted prevention and control measures.

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Section: Discussionmentioning

confidence: 99%

Analysis of the spatial-temporal distribution characteristics of hepatitis E in Jiangsu province from 2005 to 2020

Shi,

Shen,

Liu

et al. 2023

Front. Public Health

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“…HDV is the only member of the genus Deltavirus, according to the International Committee on Taxonomy of Viruses (ICTV), and belongs to the Delatviridae family [ 4 ]. Recently, HDV was reclassified with other HDV-like viruses as Kolmioviridae, the only family within a new realm, Ribozyviria, where kolmio means “triangle” in Finnish, referring to the Greek letter “Δ” (delta) [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Epidemiology Pattern, Prevalent Genotype Distribution, Fighting Stigma and Control Options for Hepatitis D in Bulgaria and Other European Countries

Tsaneva

Georgieva

2023

Life

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Hepatitis D virus (HDV) is a satellite virus that causes the most aggressive form of all viral hepatitis in individuals already infected with HBV (hepatitis B virus). In recent years, there has been a negative trend towards an increase in the prevalence of chronic hepatitis D in Europe, especially among immigrant populations coming from regions endemic for the virus. The aim of this review is to analyse the current epidemiology of chronic HDV, routes of transmission, prevalent genotype, its management, prevention, fighting stigma and options for viral control in European countries, such as Bulgaria.

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“…The hepatitis delta virus (HDV) is a member of the Kolmioviridae family and is the only human virus in the Deltavirus genus [ 1 , 2 ]. It is an RNA-defective virus that relies on coexisting with the hepatitis B virus (HBV) to become infectious, since the encapsulation of the HDV virion with hepatitis B surface antigen (HBsAg) envelope proteins enables viral entry into hepatocytes [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Phylogenetic and Phylodynamic Analysis of Delta Strains Circulating in Italy

Salichos,

Minosse,

Visco-Comandini

et al. 2023

Viruses

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The hepatitis delta virus (HDV) exhibits high genetic and evolutionary variability and is classified into eight genotypes (HDV-1 to -8). HDV-1 is the most widespread genotype worldwide and includes several subtypes. It predominates mainly in Europe, the Middle East, North America, and Northern Africa, and is associated with both severe and mild forms of liver disease. In this study, we performed phylogenetic and phylodynamic analyses of HDV strains circulating in Regione Lazio, Italy, to understand when these strains were introduced into the Lazio region and to define their genetic variability in Italy. Fifty HDV RNA positive patient samples were amplified using a nested RT-PCR approach targeting the HDV R0 region and sequenced. A phylogenetic tree of patient-derived sequences and reference sequences representing HDV-1 to -8 was constructed using the GTRGAMMA model in RAxML v8. The results indicated that HDV-1 was the predominant genotype with HDV-1d being the most frequently inferred subtype. HDV-1 sequences clustering with subtypes 1b and 1e were also identified. A phylodynamic analysis of HDV-1 sequences employing a Bayesian birth-death model inferred a clock rate of 3.04 × 10−4 substitutions per site per million years, with a 95% Highest Posterior Density (HPD) interval of 3.45 × 10−5 to 5.72 × 10−4. A Bayesian birth-death analysis with tree calibration based on a sample dating approach indicated multiple original sources of infection (from the late 1950s to late 1980s). Overall, these results suggest that HDV sequences from the native Italian and non-Italian patients analyzed in this study represent multiple lineages introduced across a wide period. A common ancestral origin should be excluded.

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Die Virushepatitiden A bis E: Prävalenz, Erregermerkmale und Pathogenese

Cited by 5 publications

References 48 publications

Analysis of the spatial-temporal distribution characteristics of hepatitis E in Jiangsu province from 2005 to 2020

Analysis of the spatial-temporal distribution characteristics of hepatitis E in Jiangsu province from 2005 to 2020

Epidemiology Pattern, Prevalent Genotype Distribution, Fighting Stigma and Control Options for Hepatitis D in Bulgaria and Other European Countries

Phylogenetic and Phylodynamic Analysis of Delta Strains Circulating in Italy

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