Die Ultrastruktur der Riechschleimhaut der neugeborenen und jugendlichen weissen Maus

Seifert, Klaus; Ule, Günter

doi:10.1007/bf00343096

Cited by 31 publications

(4 citation statements)

References 19 publications

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“…In vehicle-treated mice and untreated mice, the structure of the olfactory mucosa was similar to that previously shown by light microscopy or TEM, and there were no signs of rhinitis (5,15,28 (Fig. 3).…”

Section: Vehicle-treated Mice and Untreated Mice Light Microscopy Andsupporting

confidence: 80%

Effects of Dichlobenil on Ultrastructural Morphology and Cell Replication in the Mouse Olfactory Mucosa

1997

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The herbicide dichlobenil (2,6-dichlorobenzonitrile) is a tissue-specific toxicant inducing necrosis in the olfactory mucosa. Transmission electron microscopy showed vacuolations (1 hr) and necrosis (4 hr) in the Bowman's glands following intraperitoneal injection of dichlobenil (25 mg/kg) in C57B1 mice, whereas no lesions were noted in the olfactory neuroepithelium at these timepoints. Twentyfour hr following injection (25 mg/kg), most of the lamina propria and the olfactory epithelium were severely damaged; the basal lamina, nerves, and blood vessels in the lamina propria, however, remained intact. Following a lower dose (12 mg/kg), the lesions were not as pronounced. The effects of dichlobenil (6, 12, and 25 mg/kg) on cell replication in the olfactory mucosa, as determined by incorporation of 3H-thymidine 3 days later, were more pronounced in the lamina propria than in the neuroepithelium and occurred at a lower dose in the lamina propria than in the neuroepithelium. Together these studies support the previous proposal that dichlobenil induces a primary damage in the Bowman's glands.

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Section: Vehicle-treated Mice and Untreated Mice Light Microscopy Andsupporting

confidence: 80%

Effects of Dichlobenil on Ultrastructural Morphology and Cell Replication in the Mouse Olfactory Mucosa

1997

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“…In contrast, abundant polyribosomes and scanty rough endoplasmic reticulum were prominent in all tumours cells. These characteristics, and a high nuclear-cytoplasmic ratio, are typical of the basal cells of the olfactory epithelium (Yamamoto, 1976;Seifert & Ule, 1967). This cell type has been suggested as the stem cell from which olfactory sustentacular cells develop through differentiation (Yamamoto, 1976;Seifert & Ule, 1967).…”

Section: Resultsmentioning

confidence: 98%

“…These characteristics, and a high nuclear-cytoplasmic ratio, are typical of the basal cells of the olfactory epithelium (Yamamoto, 1976;Seifert & Ule, 1967). This cell type has been suggested as the stem cell from which olfactory sustentacular cells develop through differentiation (Yamamoto, 1976;Seifert & Ule, 1967). In view of this, the nasal-cavity tumour that was examined ultrastructurally appears to be an adenocarcinoma arising from the olfactory basal cells and displays various stages of their differentiation towards mature olfactory sustentacular cells.…”

Section: Resultsmentioning

confidence: 99%

Morphology of nasal-cavity tumours in rats after chronic inhalation of 1,2-dibromo-3-chloropropane

Reznik¹,

Reznik-Schüller²,

Ward³

et al. 1980

Br J Cancer

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Summary.-Groups of 50 F344 rats of each sex were exposed to 0-6 or 3-0 pts/106 of 1,2-dibromo-3-chloropropane (DBCP) by inhalation for 6 h/day, 5 days/week for 103 weeks. Fifty rats of each sex inhaling filtered air were used as unexposed controls. All survivors were killed at 104 weeks. Up to 93 O of the male and female rats developed neoplasms of the nasal cavity. Most of the tumours were adenomas, squamous-cell papillomas, squamous-cell carcinomas, and adenocarcinomas. In the low-dose group 780, of the tumours in males and 66% in females were benign, whereas in the high-dose groups 89% in males and 76% in females were malignant.Invasion through the cribriform plate into the cerebrum or metastasis to the regional lymph nodes was found in 730% of the carcinomas in males and 51% in females.Electron-microscopic examination suggested that the basal cells of the olfactory epithelium were the site of origin of the poorly differentiated adenocarcinomas.

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“…In the present study it has been proved in bat olfactory mucosa that epithelial cells of probably the intraepithelial duct of the olfactory gland possessed secretory granules identical with those found in the secretory portion of the olfactory gland, suggesting their secretory function. SEIFERT andULE (1967) andBREIPOHL (1972) have demonstrated dark granules in the duct epithelial cells of mouse olfactory gland, and the latter author could hardly deny a secretory activity of the duct epithelium. In olfactory glands of a variety of mammalian species, the existence of an intraepithelial duct surrounded by proper epithelial cells having no secretory function seems to be doubtful.…”

Section: Olfactory Gland (Bowman)mentioning

confidence: 99%

An Electron Microscopic Study of the Olfactory Mucosa in the Bat and Rabbit

Yamamoto

1976

Arch. Histol. Jap., Arch. Histol. Jpn

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Die Ultrastruktur der Riechschleimhaut der neugeborenen und jugendlichen weissen Maus

Cited by 31 publications

References 19 publications

Effects of Dichlobenil on Ultrastructural Morphology and Cell Replication in the Mouse Olfactory Mucosa

Effects of Dichlobenil on Ultrastructural Morphology and Cell Replication in the Mouse Olfactory Mucosa

Morphology of nasal-cavity tumours in rats after chronic inhalation of 1,2-dibromo-3-chloropropane

An Electron Microscopic Study of the Olfactory Mucosa in the Bat and Rabbit

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