Die Stickstoff bilanz zwischen Malignom und Wirt im Tiermodell

Abstract

The importance of malnutrition as major cause of morbidity and mortality in cancer patients is well documented. It has been shown that nutritional therapy improves well-being and nutritional status of the patient, but the tumor can also be accelerated by hypercaloric nutrition. Our study does not confirm the induction of tumor growth. A high positive metabolic rate of the host lowers the tumor's growth rate and its tendency to spread. The retention of nitrogen in host increase with decreasing rate of energy and nutrition. Our results show that the tumor itself uses energy and nutrients from host cell catabolism and does not directly exploit exogenous nutrient substrates. It should not be forgotten that the animal model leads to specific changes affecting the energy and nutrient metabolism.

Beeinflu�t parenterale linols�urezufuhr das Tumorwachstum?

“…Ob sic jedoch in der Lage ist, aktiv in die Tamor-Wirt-Beziehung einzugreifen, ist bisher strittig [4,18,29].…”