Die spontane maligne Transformation einer extraabdominalen Fibromatose in ein Fibrosarkom

Schwickerath, Josef; Künzig, H. J.

doi:10.1055/s-2007-1022800

Cited by 12 publications

(5 citation statements)

References 1 publication

(1 reference statement)

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“…Like extra-abdominal desmoid tumors, intrathoracic desmoid tumors demonstrate variable disease courses. Although there is a possibility of malignant transformation in extra-abdominal desmoid tumors, malignant formation in intrathoracic desmoid tumors has not yet been reported 4 8 .…”

Section: Discussionmentioning

confidence: 99%

Intrathoracic Desmoid Tumor Presenting as Multiple Lung Nodules 13 Years after Previous Resection of Abdominal Wall Desmoid Tumor

et al. 2015

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Desmoid tumors are rare soft tissue tumors considered to have locally infiltrative features without distant metastasis until now. Although they are most commonly intraabdominal, very few cases have extra-abdominal locations. The origin of intrathoracic desmoid tumors is predominantly the chest wall with occasional involvement of pleura. True intrathoracic primary desmoid tumors with no involvement of the chest wall or pleura are extremely rare. We recently experienced a case of true intrathoracic desmoid tumor presenting as multiple lung nodules at 13 years after resection of a previous intraabdominal desmoid tumor.

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Section: Discussionmentioning

confidence: 99%

Intrathoracic Desmoid Tumor Presenting as Multiple Lung Nodules 13 Years after Previous Resection of Abdominal Wall Desmoid Tumor

et al. 2015

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“…The condition is benign, despite its aggressive and locally infiltrating growth pattern. Spontaneous malignant transformation of fibromatosis of the female breast to fibrosarcoma is possible, albeit rare [21]. Two such cases have been reported [21,22].…”

Section: Discussionmentioning

confidence: 99%

Infiltrating Fibromatosis of the Female Breast: A Case Report and Review of Diagnosis and Management

Öhlinger¹,

Oellig²,

Köhler³

et al. 2002

Geburtsh u Frauenheilk

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IntroductionInfiltrating fibromatosis accounts for less than 0.2% of primary neoplastic diseases of the breast [1 ± 3]. The differential diagnosis includes other benign reactive processes (such as keloid, nodular fasciitis, radial scar, and malignant fibrous histiocytoma), low-grade spindle cell carcinoma (metaplastic), and fibrosarcoma [1,4]. The clinical, mammographic, and sonographic features of infiltrating fibromatosis are those of breast cancer. The interpretation of cytologic and histologic findings is challenging and the condition is frequently misdiagnosed as a malignant process [1,5]. ZusammenfassungFragestellung: Die infiltrative Fibromatose der Brust ist eine sehr seltene, benigne Erkrankung, die lokal aggressiv destruierend wächst, aber nicht metastasiert. Klinisch, mammographisch und sonographisch imponiert sie wie ein Mammakarzinom. Methodik: Es wird über eine 72-jährige Patientin mit einer infiltrativen Fibromatose der Brust berichtet. Ergebnisse: Die Dignitätsvorhersage ist häufig erschwert und falsch positiv, wie auch die Feinnadelaspirationszytologie, Stanzbiopsie und eine intraoperative Schnellschnittuntersuchung. Schlussfolgerung: Wir empfehlen ein zweizeitiges Vorgehen. Eine Schnellschnittuntersuchung ist wegen einer hohen Rate an falsch positiven Befunden nicht indiziert. Eine weiträumige Exzision im Gesunden ist aufgrund der hohen Rezidivneigung die Therapie der Wahl. Schlüsselwörter Infiltrative Fibromatose´Brust´Mammographie´Ultraschall AbstractWe report on a 72-year-old woman with infiltrating fibromatosis of the breast. This is a rare, benign disease with aggressive and destructive local growth but without distant spread. Wide local excision is the therapy of choice because the local recurrence rate is high. The clinical, mammographic, and sonographic features of infiltrating fibromatosis are those of breast cancer. In our patient intraoperative frozen sections led to a false diagnosis of a malignant process and mastectomy was performed. Because of frequent false positive results we recommend a two-stage approach without frozen-section histology for patients with infiltrating fibromatosis of the breast.

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“…Desmoid fibroma is a rare, semimalignant lesion, representing 1.5±3.5 % of all connective tissue tumors [20]. It originates most frequently from the aponeurosis of the rectus abdominal muscle of multipara women.…”

Section: Introductionmentioning

confidence: 99%

“…Some authors have found postoperative irradiation necessary as well [7,8]. Malignant transformation of this lesion has been described in one case only [20].…”

Section: Introductionmentioning

confidence: 99%

Extra-abdominal desmoid mimicking malignant male breast tumor

et al. 1999

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A rare case of extra-abdominal desmoid tumor is reported. A palpable mass was detected in the right breast of a 47-year-old man. Mammography showed a stellate mass without calcification, and breast ultrasound examination revealed a solid, inhomogeneous, non-calcified lesion. The result of cytological examination of the fine-needle aspiration biopsy specimen was equivocal. Histology of the surgical specimen showed extra-abdominal desmoid tumor. Extra-abdominal presentation of this semimalignant tumor is rare and may mimic malignant breast tumor. Differential diagnosis is difficult and usually based on the result of the histological examination.

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Die spontane maligne Transformation einer extraabdominalen Fibromatose in ein Fibrosarkom

Cited by 12 publications

References 1 publication

Intrathoracic Desmoid Tumor Presenting as Multiple Lung Nodules 13 Years after Previous Resection of Abdominal Wall Desmoid Tumor

Intrathoracic Desmoid Tumor Presenting as Multiple Lung Nodules 13 Years after Previous Resection of Abdominal Wall Desmoid Tumor

Infiltrating Fibromatosis of the Female Breast: A Case Report and Review of Diagnosis and Management

Extra-abdominal desmoid mimicking malignant male breast tumor

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