“…The overwhelming preference of males between 20 and 40 years of age, as well as secondary pneumatization especially of the frontal sinuses, which is frequently observed in acromegalic patients, indicates that a hormonal factor is involved. Association with meningiomas has frequently been described and is known as "blistering" and as being associated with sclerotic bone changes of the planum sphenoidale or tuberculum sellae (Olivecrona 1927;Schuller 1930;Decker 1960;Psenner 1963;Beutel and Tanzer 1963;Lombardi et al 1968;Wiggly et al 1975;Leonardi and Fabris 1976;Hirst et al 1979: 1982, andothers). Other pathological conditions associated with focal pneumosinus dilatans are hemangiomas (Mayer 1959;Susse 1964), particularly in connection with systemic diseases such as Klippel-Trenaunay-Weber syndrome or Sturge-Weber syndrome, Recklinghausen's disease, and other phacomatoses (Psenner 1963;Weikmann 1958;Spoor et al 1981).…”