Die Rolle der Mikrozirkulation in der Entstehung des Organversagens

Noitz, Matthias; Steinkellner, Christoph; Willingshofer, Mark Philipp; Szasz, Johannes; Dünser, Martin W.

doi:10.1055/a-1226-9091

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…The role of microcirculation dysfunction is strongly associated with the severity of organ dysfunction and mortality [27,28]. The nature and degree of microcirculatory dysfunction are pronounced in patients with inflammatory activation [29].…”

Section: Discussionmentioning

confidence: 99%

Coronary Artery Disease and Inflammatory Activation Interfere with Peripheral Tissue Electrical Impedance Spectroscopy Characteristics—Initial Report

Urbanowicz

Michalak

Marzec

et al. 2023

IJERPH

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Background: The electrical properties of cells and tissues in relation to energy exposure have been investigated, presenting their resistance and capacitance characteristics. The dielectric response to radiofrequency fields exhibits polarization heterogeneity under pathological conditions. The aim of the study was to analyze the differences in changes in resistance and capacitance measurements in the range from 1 kHz to 1 MHz, combined with an assessment of the correlation between the results of electrical impedance spectroscopy (EIS) and inflammatory activation. Methods: In the prospective study, EIS was performed on the non-dominant arm in 29 male patients (median (Q1–Q3) age of 69 (65–72)) with complex coronary artery disease and 10 male patients (median (Q1–Q3) age of 66 (62–69)) of the control group. Blood samples were collected for inflammatory index analysis. Results: The logistic regression analysis revealed a negative correlation with inflammatory indexes, including neutrophil to lymphocyte ratio (NLR) in the CAD group in the frequency of 30 kHz (p = 0.038, r = −0.317) regarding EIS resistance measurements and a positive correlation in CAD group in the frequency of 10 kHz (p = 0.029, r = −0.354) regarding EIS capacitance. Conclusions: The bioelectric characteristics of peripheral tissues measured by resistance and capacitance in EIS differ in patients with coronary artery disease and in the control group. Electrical impedance spectroscopy reveals a statistically significant correlation with inflammatory markers in patients with CAD.

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Section: Discussionmentioning

confidence: 99%

Coronary Artery Disease and Inflammatory Activation Interfere with Peripheral Tissue Electrical Impedance Spectroscopy Characteristics—Initial Report

Urbanowicz

Michalak

Marzec

et al. 2023

IJERPH

View full text Add to dashboard Cite

show abstract

“…( 10 ) An endothelial dysfunction damages the relaxation functions of the blood vessels, leading to microcirculation dysfunction to promote the deterioration of sepsis. ( 11 ) Therefore, it is of great clinical significance to improve tissue microcirculation in sepsis.…”

Section: Introductionmentioning

confidence: 99%

Estrogen receptor subtype mediated anti-inflammation and vasorelaxation via genomic and nongenomic actions in septic mice

et al. 2023

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AimSepsis is a life-threatening disease with high mortality worldwide. Septic females have lower severity and mortality than the males, suggesting estrogen exerts a protective action, but nothing is known about the role of vascular endothelial estrogen receptor subtypes in this process. In the present study, we aimed to study the estrogen receptors on mesenteric arterioles in normal and sepsis mice and to elucidate the underlying mechanisms.MethodsSepsis was induced in mice by intraperitoneal injection of LPS. The changes in the expression and release of the serum and cell supernatant proinflammatory cytokines, including TNF-α, IL-1β and IL-6, were measured by qPCR and ELISA, and the functions of multiple organs were analyzed. The functional activities of mouse mesenteric arterioles were determined by a Mulvany-style wire myograph. The expression of phospholipase C (PLC) and inositol 1,4,5-trisphosphate receptor (IP3R) in endothelial cells were examined by Western blot and their functions were characterized by cell Ca2+ imaging.ResultsSeptic female mice had higher survival rate than the male mice, and pretreatment with E2 for 5 days significantly improved the survival rate and inhibited proinflammatory cytokines in septic male mice. E2 ameliorated pulmonary, intestinal, hepatic and renal multiple organ injuries in septic male mice; and ER subtypes inhibited proinflammatory cytokines in endothelial cells via PLC/IP3R/Ca2+ pathway. E2/ER subtypes immediately induced endothelial-derived hyperpolarization (EDH)-mediated vasorelaxation via PLC/IP3R/Ca2+ pathway, which was more impaired in septic male mice. E2/ER subtypes could rescue the impaired acetylcholine (ACh)-induced EDH-mediated vasorelaxation in septic male mice.ConclusionsE2 through ER subtypes mediates anti-inflammation and vasorelaxation via genomic and nongenomic actions in sepsis. Mechanistically, activation of endothelial ER subtypes reduces proinflammatory cytokines and induces EDH-mediated vasorelaxation via PLC/IP3R/Ca2+ pathway, leading to amelioration of sepsis-induced organ injury and survival rate.

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Die Rolle der Mikrozirkulation in der Entstehung des Organversagens

Cited by 2 publications

References 22 publications

Coronary Artery Disease and Inflammatory Activation Interfere with Peripheral Tissue Electrical Impedance Spectroscopy Characteristics—Initial Report

Coronary Artery Disease and Inflammatory Activation Interfere with Peripheral Tissue Electrical Impedance Spectroscopy Characteristics—Initial Report

Estrogen receptor subtype mediated anti-inflammation and vasorelaxation via genomic and nongenomic actions in septic mice

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