Die psychische Wirkung der mexikanischen Droge ?Ololiuqui? am Menschen

Heim, Eva; Heimann, H; Lukács, G.

doi:10.1007/bf00401617

Cited by 17 publications

(6 citation statements)

References 5 publications

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Section: Resultsmentioning

confidence: 99%

“…A total of 21 studies ( n = 553) investigated memory performance under the influence of ayahuasca 79 , DOM 83 , 84 , LSA 72 , LSD 74 , 75 , 82 , 85 – 92 , 2C-B 93 and psilocybin 71 – 73 , 93 – 96 , utilizing 22 distinct memory tests. The majority of studies (1 LSA, 3 psilocybin, 6 LSD, 1 DOM) 72 – 74 , 82 , 84 , 85 , 88 – 90 , 95 , 96 did not show any acute effects of psychedelics on memory across fifteen tasks. On the other hand, eleven studies (4 psilocybin, 1 2C-B, 6 LSD, 1 ayahuasca) 71 , 72 , 75 , 79 , 82 , 86 , 87 , 91 – 94 demonstrated impaired memory performance across twelve tasks, while only one study (DOM) 83 using one task showed improved memory performance.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Cognitive functioning associated with acute and subacute effects of classic psychedelics and MDMA - a systematic review and meta-analysis

Basedow,

Majić,

Hafiz

et al. 2024

Sci Rep

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Classic psychedelics and MDMA have a colorful history of recreational use, and both have recently been re-evaluated as tools for the treatment of psychiatric disorders. Several studies have been carried out to assess potential long-term effects of a regular use on cognition, delivering distinct results for psychedelics and MDMA. However, to date knowledge is scarce on cognitive performance during acute effects of those substances. In this systematic review and meta-analysis, we investigate how cognitive functioning is affected by psychedelics and MDMA during the acute drug effects and the sub-acute (“afterglow”) window. Our quantitative analyses suggest that acute cognitive performance is differentially affected by psychedelics when compared to MDMA: psychedelics impair attention and executive function, whereas MDMA primarily affects memory, leaving executive functions and attention unaffected. Our qualitative analyses reveal that executive functioning and creativity may be increased during a window of at least 24 h after the acute effects of psychedelics have subsided, whereas no such results have been observed for MDMA. Our findings may contribute to inform recommendations on harm reduction for recreational settings and to help fostering differential approaches for the use of psychedelics and MDMA within a therapeutic framework.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Cognitive functioning associated with acute and subacute effects of classic psychedelics and MDMA - a systematic review and meta-analysis

Basedow,

Majić,

Hafiz

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…25 This compound was later isolated from ololiuqui and found to be one of its less psychoactive constituents insofar as oral doses of 8 mg merely induced slight sedation in volunteers. 26 Lysergol has been a valuable intermediate in the preparation of semi-synthetic analogues since its tosylate or mesylate heated with a thiol compound in a polar solvent readily underwent nucleophilic displacement, thereby introducing a sulfur-containing side chain. Pergolide was prepared in this manner by Lilly researchers and shown to be a potent dopamine receptor agonist.…”

Section: Pergolidementioning

confidence: 99%

Analogues of Pharmacodynamic Agents from Fungi

Sneader

2005

Drug Discovery

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“…Im direkten Vergleich der Einzelsubstanzen mit dem Gemisch zeigt sich, dass es sich bei diesen Alkaloiden um die Hauptwirkstoffe handelt [10,11,14].…”

Section: Introductionunclassified

“…Argyreia nervosa: prozentuale Anteile der einzelnen Alkaloide am Gesamtalkaloidgemisch[5] durch starke vegetative Störun-gen gekennzeichnete, vorwiegend sedierende Intoxikation, die sich am ehesten mit der Wirkung von Scopolamin vergleichen lässt"[10,11]. Einschränkend ist anzumerken, als dass Scopolamin im Gegensatz zu LA und LAE eine ausgepräg-te Mundtrockenheit hervorruft[19].Im Rahmen einer neuen Jugendbewegung ("Techno-Kultur") werden wieder verstärkt halluzinogene Stoffe konsumiert.…”

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Hawaiianische Holzrose: (Psycho-)Pharmakologische Wirkungen der Samen der Argyreia nervosa Eine fallbezogene Darstellung

et al. 2002

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The seeds of the Hawaiian baby woodrose ( Argyreia nervosa) are used by adolescents as a supposed hallucinogenic drug. These seeds are legally available and broadly sold. The active components are alkaloids structurally related to lysergic acid diethylamide (LSD). However, the psychic effects are very different from those of LSD and are dominated by rather sedative, uncomfortable autonomic disturbances similar to the effects of scopolamine. The (psycho)pharmacological profile is described on the basis of the active substances lysergacidamide and lysergacidethylamide (and their isomers). It is shown that neither the substances themselves nor the mixture are able to evoke LSD-like perceptual variances. The exposure of Argyreia nervosa is described focusing on potential fetal distress by contained ergometrine and the case history of an intoxication.

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Die psychische Wirkung der mexikanischen Droge ?Ololiuqui? am Menschen

Cited by 17 publications

References 5 publications

Cognitive functioning associated with acute and subacute effects of classic psychedelics and MDMA - a systematic review and meta-analysis

Cognitive functioning associated with acute and subacute effects of classic psychedelics and MDMA - a systematic review and meta-analysis

Analogues of Pharmacodynamic Agents from Fungi

Hawaiianische Holzrose: (Psycho-)Pharmakologische Wirkungen der Samen der Argyreia nervosa Eine fallbezogene Darstellung

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