Die problematik der appendicitis im s�uglings- und kindesalter

Schütze, U; Daum, R.; Tessmar, J

doi:10.1007/bf01261704

Cited by 5 publications

(1 citation statement)

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“…Since appendectomies performed for a variety of complaints diagnosed as "chronic appendicitis" did not have the expected results, the coneept of chronic inflammatory lesions of the appendix has fallen into disfavor (3,8,10,12). However, recent investigations of large series of patients have re-established the concept of chronic appendieitis which is thought to account for about 6-8 % of all appendix cases (13,17,20,21). However, the preeise disease mechanism has not yet been fully established.…”

Section: Methodsmentioning

confidence: 99%

Chronic Recurrent Appendicitis. A Clinicopathologic Study of 47 Cases*

Falk¹,

Schütze²,

Guth³

et al. 1991

Eur J Pediatr Surg

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As part of a retrospective study 47 appendices from patients with a clinical and morphologic diagnosis of chronic recurrent appendicitis were studied by morphologic and immunohistochemical methods. Appendices with chronic recurrent appendicitis histologically show chronic active inflammation with increased numbers of immunocompetent cells, mostly T lymphocytes and subsequent scarring. In addition, there is an increase in the number of neural cells. Apparently the secretion of neurotropic inflammatory mediators, especially by activated and degranulating eosinophils, leads to a stimulation of nociceptive receptors and thus to the clinical symptoms. The diagnosis of recurrent chronic appendicitis is thus warranted in these cases not only clinically but also on the basis of histologic and immunohistochemical findings.

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Section: Methodsmentioning

confidence: 99%