Die Plasma-Renin-Aktivität beim Phäochromozytom^*

Abstract

Scornik und Paladini (36) stellten zum Beispiel nach intravenösen Infusionen von Noradrenalin einen signifikanten Anstieg des Plasma-Angiotensins fest. Wathen und Mitarbeiter (49) fanden bei Tierexperimenten eine Reninstimulation, wenn die Katecholamine direkt in die Nierenarterie gegeben wurden, bei intravenösen Gaben blieb die Stimulation des Renins jedoch aus. Vander (45) sah demgegenüber auch nach intravenöser Verabreichung von Katecholaminen eine deutliche Reninerhöhung bei Hunden.

Coexistence of bilateral adrenal phaeochromocytoma and Idiopathic hyperaldosteronism

“…Although adrenaline hypersecretion may have directly contributed to the hypokalaemia found in our patient (Brown et al, 1983), it does not explain the documented primary hyperaldosteronism. Hypersecretion of renin and aldosterone has been reported in some patients with phaeochromocytoma (Werning et al, 1970;Wilson et al, 1973). Hyperaldosteronism in these circumstances can be categorized as secondary or primary aldosteronism (Fig.…”

Metabolic Studies in a Patient With a Phaeochromocytoma Associated With Hypokalaemia and Hyperaldosteronism

“…Ganong (1972) has summarized evidence that the sympathetic nervous system increases renin secretion by way of a /^-adrenergic receptor mechanism, and that the increase in plasma renin induced by increasing plasma catecholamine levels may be potentiated by a-adrenergic blockade and is abolished by /?-adrenergic blockade. Plasma renin has been found to be increased in some cases of phaeochromocytoma (Werning, Zeigler, Baumann, Endres, Gysling, Weidman & Seigenthaler, 1970).…”

Acute and chronic intrarenal alpha- and beta- adrenergic receptor stimulation of renin release in the conscious dog.

“…Two well-known clinical entities, pheochromocytoma 19 ' *° and congestive heart failure, 11 may be associated with normal PRA in the presence of increased circulating norepinephrine levels. These findings, together with our observation that PRA returns to baseline within 24 to 48 hours during continuous intrarenal norepinephrine infusion, suggested to us that juxtaglomerular cell 0-adrenergic receptor refractoriness might occur.…”