Die Picrocarminfärbung und ihre Anwendung auf die Entzündungslehre

Streptococcal Rheumatic Carditis.

“…McEwan (169) lists the suggested origins of fixed connective tissue cells. The two major theories are that (i) the Aschoff cells are nonmyogenic mesenchymal cells (9,15,139,148,187,199,243,259,276,279) and (ii) they are myogenetic in origin (5,18,174,180,182,183,277). According to Becker and Murphy (18), Aschoff bodies are central to the pathology of rheumatic heart disease, which is in opposition to Stollerman's (249,250) opinion that Aschoff lesions cannot account for the serious myocardial failure of severe rheumatic carditis.…”

“…The term fibrinoid degeneration was introduced by Neumann in 1880 (187) to describe the structural changes perceived in the connective tissues of serous, synovial, and mucous membranes and of vascular intima and endocardium due to inflammation. The fibrinoid substance that he saw resembled fibrin and had the same staining properties.…”

Streptococcal rheumatic carditis.

“…McEwan (169) lists the suggested origins of fixed connective tissue cells. The two major theories are that (i) the Aschoff cells are nonmyogenic mesenchymal cells (9,15,139,148,187,199,243,259,276,279) and (ii) they are myogenetic in origin (5,18,174,180,182,183,277). According to Becker and Murphy 18, Aschoff bodies are central to the pathology of rheumatic heart disease, which is in opposition to Stollerman's (249, 250) opinion that Aschoff lesions cannot account for the serious myocardial failure of severe rheumatic carditis.…”

“…The nature of fibrinoid. The term fibrinoid degeneration was introduced by Neumann in 1880 (187) to describe the structural changes perceived in the connective tissues of serous, synovial, and mucous membranes and of vascular intima and endocardium due to inflammation. The fibrinoid substance that he saw resembled fibrin and had the same staining properties.…”

What stuff is this! A historical perspective on fibrinoid necrosis

“…According to the Oxford English Dictionary 1, the first written reference to the word fibrinoid stems from 1880, when Neumann published an article on the application of a staining method, the so‐called picrocarmine staining. The purpose of the article was to bring forward a reliable protocol for this staining technique, that would highlight ‘fibrinoide Degeneration’ occurring in serous, mucous, synovial, and endothelial surfaces as a result of inflammation, a change which could be easily overlooked with other staining methods: ‘sodass es trotz der Häufigkeit seines Vorkommens und seiner unzweifelhaft wichtigen Bedeutung für die bei jenen Prozessen auftretenden makroskopischen Veränderungen von den pathologischen Histologen bisher nicht genügend gewürdigt worden ist’** 2.…”