Die pathologische Anatomie der Herzinsuffizienz

Linzbach, A. J.

doi:10.1007/978-3-642-94786-5_4

Cited by 23 publications

(1 citation statement)

References 144 publications

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“…For example, pressure overload leads to concentric hypertrophy while volume overload leads to eccentric hypertrophy ( 1). Systolic contractile function is depressed in pressure overload hypertrophy (2) but is normal in volume overload hypertrophy (3).…”

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confidence: 99%

A New Technique for Production of Chronic Atrial Septal Defect in Cat without Thoracotomy

Natarajan¹,

Carey²,

Coulson³

et al. 1979

Experimental Biology and Medicine

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Cardiac hypertrophy resulting from pressure overload and from volume overload differ considerably in many respects. For example, pressure overload leads to concentric hypertrophy while volume overload leads to eccentric hypertrophy ( 1). Systolic contractile function is depressed in pressure overload hypertrophy (2) but is normal in volume overload hypertrophy (3). Studies utilizing experimentally produced pressure overload hypertrophied right ventricular papillary muscles of small mammals like cats (3-6) and rabbits (7, 8) have contributed considerably to the understanding of changes in myocardial function in cardiac hypertrophy. A surgically produced atrial septal defect in cats has been shown by Cooper et al.(3) to cause volume overload right ventricular hypertrophy which is another useful model for the study of cardiac hypertrophy. However, the surgical technique requires thoracotomy and pericardiotomy. A nonsurgical technique to create an atrial septal defect would facilitate further studies of volume overload cardiac hypertrophy. Accordingly, a new technique using a flexible bronchoscopy biopsy forceps was developed.Methods. The cat is lightly anesthetized with sodium pentobarbital, 30 mg/kg administered intraperitoneally, and allowed to breathe spontaneously. The left femoral vein and the external jugular vein and carotid artery in the neck are exposed. The ascending aorta and the right ventricle are catheterized with a 5 F NIH catheter and a 5 F Goodale '

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confidence: 99%