Die Pathologie der Bindegewebs-geschwülste und Mischgeschwülste

Meyer, Robert

doi:10.1007/978-3-642-96019-2_2

Cited by 7 publications

(5 citation statements)

References 317 publications

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“…These findings are in accordance with our own experience and experience reported by others: before the size of the node declines, symptoms initially improve [ 14 ]. Despite the higher local dosage of dienogest, a reduction in the size of rectovaginal endometriosis nodes can probably only be observed clinically later on, since rectovaginal endometriosis always represents as adenomyofibromatous lesion [ 15 ], treatment-related remission of which takes time [ 16 ]. Dienogest was effectively resorbed vaginally, leading to therapeutic amenorrhea and the corresponding hormone findings in the present patient.…”

Section: Discussionmentioning

confidence: 99%

Daily Vaginal Application of Dienogest (Visanne©) for 3 Months in Symptomatic Deeply Infiltrating Rectovaginal Endometriosis: A Possible New Treatment Approach?

Ebert¹

2018

Case Reports in Obstetrics and Gynecology

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A 27-year-old patient suffering from deeply infiltrating rectovaginal endometriosis was treated with 2 mg/day dienogest vaginally for 3 months. The therapy was tolerated very well. The patient reported less side effects compared to the oral use of dienogest. After 3 months of dienogest treatment, the rectovaginal gynecological examination identified the visible vaginal part of endometriosis in remission. The firm endometriosis node approximately 3 cm in size and approximately 10 cm ab ano was still palpable, but it was much less painful. The laboratory values for luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were unremarkable, with an LH/FSH quotient of 0.7 during dienogest treatment, while 17-β estradiol and progesterone were suppressed. At palpation and vaginal ultrasonography, there was no change in the findings before and after 3 months of dienogest treatment, but the patient was now de facto asymptomatic. To the best of our knowledge, this is the first report of a vaginal dienogest treatment in symptomatic deeply infiltrating rectovaginal endometriosis. Vaginal administration of dienogest should receive further investigation in pharmacokinetic and clinical studies.

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Section: Discussionmentioning

confidence: 99%

Daily Vaginal Application of Dienogest (Visanne©) for 3 Months in Symptomatic Deeply Infiltrating Rectovaginal Endometriosis: A Possible New Treatment Approach?

Ebert¹

2018

Case Reports in Obstetrics and Gynecology

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“…The classic peritoneal implant is a blue-black "powder burn" lesion with varying amounts of surrounding fibrosis, typically observed on the ovaries and on peritoneal surfaces in the cul-de-sac, uterosacral ligaments, and ovarian fossa. 11 Less commonly, disease may be found in ovarian adhesions, yellow-brown patches, in peritoneal defects, or involving the appendix. 11 Red lesions are highly vascular, proliferative, and represent an early stage of disease.…”

Section: Discussionmentioning

confidence: 99%

“…11 Less commonly, disease may be found in ovarian adhesions, yellow-brown patches, in peritoneal defects, or involving the appendix. 11 Red lesions are highly vascular, proliferative, and represent an early stage of disease. Pigmented lesions represent more established or advanced disease.…”

Section: Discussionmentioning

confidence: 99%

Incidental detection of atypical endometriosis during caesarean section suspicious of malignancy-a case report

Tejaswini¹,

ushree²,

Kumar³

et al. 2018

EMIJ

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Endometriosis is defined as presence of endometrium including glands and stroma at locations other than the uterine cavity. Atypical endometriosis is rarely seen, accounting for 4.38% amongst endometriosis cases and is reported to possess a precancerous potential. We are reporting a case of primigravida with term gestation, taken up for emergency caesarean section in view of severe preeclampsia with imminent signs of eclampsia. Intraoperatively left ovary was adherent to posterior uterine wall and a cauliflower like growth was seen extending from posterior part of left mesosalphinx, left ovary, posterior uterine wall upto pouch of douglas. Biopsy was taken from the growth and its histopathological examination was reported as atypical endometriosis. Postoperatively patient was stable and was discharged on postoperative day 8.

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“…On the other hand, cells of the basal layer can also continually infiltrate the myometrium, giving rise to the fully developed clinical picture of uterine adenomyosis. Endometriosis and adenomyosis are two sides of the same coin (1,6,7). There are likely to be stem cells in the basal endometrial layer that play an essential role both in the cyclical regeneration of eutopic endometrial tissue and in endometriosis (12).…”

Section: Etiologymentioning

confidence: 99%

“…Endometriosis tissue is biologically the same as basal endometrial tissue. Foci of endometriosis consist of glands, stroma cells, and smooth muscle; they are supplied by nerves (neurogenesis), lymphatic vessels, and blood vessels (angiogenesis) (1)(2)(3)(4)(5). Endometriosis cells express estrogen receptors (ER α/β) and progesterone receptors (PR A/B) and therefore respond to endocrine treatments (6,7).…”

mentioning

confidence: 99%

The Diagnosis and Treatment of Deep Infiltrating Endometriosis

Halis¹,

Mechsner²,

Ebert³

2010

Deutsches Ärzteblatt International

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The main manifestations are primary or secondary dysmenorrhea, bleeding disturbances, infertility, dysuria, pain on defecation (dyschezia), cycle-dependent or (later) cycle-independent pelvic pain, nonspecific cycle-associated gastrointestinal or urogenital symptoms. Cycle-associated problems of urination and/or defecation that are due to endometriosis are most common in young, premenopausal women. Whenever such manifestations are present, endometriosis should be considered in the differential diagnosis, and evidence for it should be sought in the clinical history, physical examination, and ultrasound findings. If endometriosis is histologically confirmed and is of the deeply infiltrating kind, the recommended management today is to refer the patient to an endometriosis center.

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Die Pathologie der Bindegewebs-geschwülste und Mischgeschwülste

Cited by 7 publications

References 317 publications

Daily Vaginal Application of Dienogest (Visanne©) for 3 Months in Symptomatic Deeply Infiltrating Rectovaginal Endometriosis: A Possible New Treatment Approach?

Daily Vaginal Application of Dienogest (Visanne©) for 3 Months in Symptomatic Deeply Infiltrating Rectovaginal Endometriosis: A Possible New Treatment Approach?

Incidental detection of atypical endometriosis during caesarean section suspicious of malignancy-a case report

The Diagnosis and Treatment of Deep Infiltrating Endometriosis

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