Die Papierelektrophorese der Eiweiβkörper des Liquor cerebrospinalis

Habeck, Dietrich

doi:10.1159/000133845

Cited by 16 publications

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“…Seit Esser und Heinzier 1952 Liquor-Beta-Globulinvermehrungen bei Hydrocephalus internus berichteten, beschäftigt sich eine Reihe von Publikationen mit der diagnostischen Bedeu tung der Liquor-Beta-Globuline. Einige Autoren vertreten die Ansicht, daß insbesondere bei degenerativen Erkrankungen des Gehirns liquorelektrophoretisch Beta-Globulinvermehrungen gefunden werden können (Bauer 1953,Ce~o~Nava"a,AIatwr 1959,Dewnk 1957, 1965, Esser, Heinzier 1952, Fekas 1959, Habeck 1960, 1962,AIatiar 1960, Schmidt 1968,Steger 1953. Laterre hatte deshalb 1965 den Begriff des "degenerativen Typs" der Liquorelek trophorese vorgeschlagen.…”

Section: Introductionunclassified

Zur Frage der Herkunft und der diagnostischen Bedeutung der Liquor-Beta-Globuline

Wu¹,

Henzi²

1980

Fortschr Neurol Psychiatr

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208 cerebrospinal fluid samples were taken from patients having various patterns of neurological diseases. The following beta-globulins: transferrin, haemopexin, beta-1 A-globulin, beta-1 E-globulin, beta-2-glycoproteid and beta-lipoproteid were determined immunologically quantitatively in the CSF and partly quantitatively in the serum, and their behaviour was compared with that of the beta and tau fraction in CSF electrophoresis. It was found that changes in the fractions in CSF electrophoresis agreed only slightly with those of the quantitatively determined globulins, although these globulins represent 70--80% of the beta and tau fraction. Increases in the number of beta-1 A and beta-1 E-globulins are more significantly marked in intracranial haemorrhages than with other diseases. In all other respects, increases or decreases in the number of beta-globulins do not appear to be typical of any particular disease pattern determined by electrophoresis or quantitatively. Due to the linearity of the changes in case of disturbances of the CSF barrier, and also on account of the absolutely parallel behaviour of the beta-globulins, it was concluded that transferrin--contrary to the opinion held so far--is produced cerebrally in only small quantities or possibly not at all, and that the entirety of beta-globulins originate from the serum.

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Section: Introductionunclassified