Die Nebenniere

Stimulus‐secretion coupling: the concept and clues from chromaffin and other cells

“…There is, of course, an alternative mechanism of secretion that would account equally well for the simultaneous discharge of the various constituents of the chromaffin granules, namely, that chromaffin granules are extruded intact as suggested by various authors on microscopical evidence (Cramer, 1928;Smitten, 1965;Gori, 1964; see also review by Bachmann, 1954). But this seems to be excluded by other chemical evidence we have obtained more recently which shows: first, that efflux of phospholipid and cholesterol, the principal lipids of the chromaffin granule membrane, rises little, if at all, on stimulation (Trifaro, ; see also Schneider, Smith & Winkler, 1967); second, that there is no fall in the phospholipid and cholesterol contents of a sub-cellular fraction containing the chromaffin granules following medullary stimulation (Poisner, Trifaro & Douglas, 1967); and, third, that electronmicrographs of these fractions recovered after stimulation are rich in profiles with the appearance of empty granules (Malamed, Poisner, Trifaro & Douglas, 1968).…”

“…The analysis of the blocking action of amethocaine is, in fact, fresh pharmacological support for the view that calcium entry is important for secretion while sodium entry is not. Bachmann, 1954;Franzen, 1964;Grauman, 1956). Nor has the problem been solved with the advent of electronmicroscopy and techniques of cell fractionation.…”

The Relationship between Mast Cells and Histamine in Phylogeny with Special Reference to Reptiles and Birds

“…This type of cell called "summer cell" or "Stilling cell" (Fig. 6) and known to contain acidophilic and PAS positive granules has been considered a derivative of the mast cell by some authors (see BACHMANN, 1954).…”

Histological, physiological and biochemical studies on the heart of two cyclostomes, hagfish (Myxine) and lamprey (Lampetra)

“…Perhaps the chromaffin cells of the Lampetra heart represent from a phylogenetical point of view a primitive type of sympathetic (adrenergic) neurone. It is worth mentioning in this connexion that in higher vertebrates the chromaffin cells of the adrenal medulla emerge ontogenetically from the same source as sympathetic neurones (Bachmann, 1954). STUDIES ON CYCLOSTOME HEARTS There is also a difference in the response to acetylcholine and certain other substances between the heart of Myxine and of Lampetra.…”