Die Milchdrüse

Dabelow, Adolf

doi:10.1007/978-3-642-47921-2_2

Cited by 14 publications

(10 citation statements)

References 346 publications

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“…One of the most interesting features of the mammary gland is the capacity to maintain an abundant supply of self renewing, undifferentiated stem cells [1, 2, 3, 4, 5, 6]. Mammary epithelial stem cells are believably the targets for the development of breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Identification of Stem Cell Units in the Terminal End Bud and Duct of the Mouse Mammary Gland

Kenney

Smith

Lawrence

et al. 2001

BioMed Research International

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The mouse mammary gland may undergo cycles of proliferation, terminal differentiation, tissue remodeling, and more importantly malignant transformation. Mammary epithelial stem cells and their progeny participate in these processes. Mammary epithelial stem cells are multipotent, exhibit properties of self renewal (up to 7 divisions) and may exist either as long-lived nondividing cells or as proliferating-differentiating cells. The focus of this study was to locate stem cells by identifying them as long-lived, label-retaining mammary epithelial cells (LRCs) in growth active (developing) or growth static (aged) mammary ducts. Initially, primary epithelial cells were pulse labeled with either fluorescent tracker dye and/or BrdU. Cells were then transplanted into cleared juvenile syngeneic mammary fat pads and held for 5 weeks or 8 weeks. In this study, we demonstrate that LRCs are stem cells and their progeny (transitional cells) are arranged as transitional units (TUs). Additionally, TUs are located every 250 ± 75 μm in ducts or in the terminal end bud 200–600 μm in diameter. Molecules expressed in TUs were Zonula Occludens-1 and α-catenin proteins which were significantly detected in 75%–91% (P < 0.001) of the LRCs cells that make up the TU. These data suggest that transitional units may be a group of label-retaining stem cells and maybe involved in the developmental or cancer process.

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Section: Introductionmentioning

confidence: 99%

Identification of Stem Cell Units in the Terminal End Bud and Duct of the Mouse Mammary Gland

Kenney

Smith

Lawrence

et al. 2001

BioMed Research International

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“…It is agreed that the developmental phase of the human breast starts as early as the stage of nipple epithelium during embryonic development, continuing steadily with body growth, and undergoing a spurt of growth with lobule formation at puberty [1][2][3]. Lobular formation is accomplished by interaction of two processes, development and differentiation, both of which take place almost simultaneously [l, 2,5].…”

Section: Introductionmentioning

confidence: 99%

Influence of age and parity on the development of the human breast

Russo

Ramírez

Russo

1992

Breast Cancer Res Tr

211

167

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Breast cancer is heavily influenced by the reproductive history of the individual. Pregnancy has a protective effect which is attributed to differences in the degree of differentiation of the breast. The purpose of this work was to determine whether the quantity and the type of parenchymal structures present in the human breast were related to the age and parity history of a woman. Fifty-one human breast samples were obtained from bilateral or unilateral reduction mammoplasties performed in 40 parous women ranging in age from 18 to 57 years, and 11 nulliparous women ranging in age from 14 to 54 years. An average of 100 grams of tissue/specimen were processed for whole mount. A total of 650 slides were examined and 31,222 structures were classified and counted under the light microscope. The following mammary structures were identified: terminal structures (TS), and lobules (LOB) type 1, 2, and 3. Results were plotted for the total patient population and separately for nulliparous and parous women against age. The total patient population contained similar proportions of LOb1, 2, and 3 between ages 14-18, with a reduction of percentage of Lob1 and increase in Lob3 between ages 23 to the middle forties, when Lob3 decreased and Lob1 increased to 70%. Lob2 and TS did not exhibit significant changes throughout the period of life analyzed. When analyzed separately it was found that the breasts of nulliparous women were predominantly composed of Lob1, fewer Lob2, with Lob3 almost completely absent, whereas parous women had a high frequency of Lob3, which were the predominant structures until the fourth decade of life.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…The resulting fragments subside but leave behind elevated streak-like segments that eventually form into round buds [34, 35]. As no elevated ridge was observed in mouse embryos, the formation of a mammary line in mouse embryos was considered controversial [75–77] and the onset of mammary gland formation was consequently believed to be essentially different between mouse and rabbit. Nonetheless, a streak of expression of Wnt10b (encoding a secreted factor) on the mouse embryonic flank was assumed to mark a mammary line [78].…”

Section: Time To Revise Some Long-standing Concepts?mentioning

confidence: 99%

Prenatal Morphogenesis of Mammary Glands in Mouse and Rabbit

Propper

Howard

Veltmaat

2013

J Mammary Gland Biol Neoplasia

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Our understanding of prenatal morphogenesis of mammary glands has recently greatly advanced. This review focuses on morphogenesis proper, as well as cellular processes and tissue interactions involved in the progression of the embryonic mammary gland through sequential morphogenic stages in both the mouse and rabbit embryo. We provide a synthesis of both historical and more recent studies of embryonic mammary gland development, as well as arguments to revise old concepts about mechanisms of mammary line and rudiment formation. Finally, we highlight outstanding issues that remain to be addressed.

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Die Milchdrüse

Cited by 14 publications

References 346 publications

Identification of Stem Cell Units in the Terminal End Bud and Duct of the Mouse Mammary Gland

Identification of Stem Cell Units in the Terminal End Bud and Duct of the Mouse Mammary Gland

Influence of age and parity on the development of the human breast

Prenatal Morphogenesis of Mammary Glands in Mouse and Rabbit

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