Die magische Kraft der Übergangsmetalle: Vergangenheit, Gegenwart und Zukunft (Nobel‐Aufsatz)

Abstract

In meinem ersten Jahr an der Shonan errang damit den 123. Platz der schulischen Leistung unter etwas mehr als 400 Mitschülern. Nach einem kurzen Augenblick der Enttäu-schung erkannte ich, dass zwar etwas mehr als 100 Schüler vor mir lagen, aber auch fast 300 hinter mir. Damals wurden jährlich etwa 30-40 Schüler von Shonan einschließlich der einmaligen Wiederholer an der Universität Tokio aufgenommen. Mir wurde dann plötzlich klar, dass ich sogar eine berechtigte Chance hätte, an die bis dahin für mich unerreichbar scheinende Universität Tokio zu kommen, wenn ich so hart wie möglich lernte.

Reactivity of TpMe2‐Supported Yttrium Alkyl Complexes toward Aromatic N‐Heterocycles: Ring‐Opening or CC Bond Formation Directed by CH Activation

“…Crystal and data collection parameters of complexes 5-8. (2) 293 (2) 293 (2) 293(2) scan type w-2q w -2q w -2q w -2q q range [8] 1 …”

“…293 (2) 293 (2) 293 (2) 293(2) scan type w-2q w -2q w -2q w -2q q range [8] 1.39 to 25.00 1.703 to 25.010 1.61 to 26.01 2.14 to 25.50 Chem. Eur.…”

“…[6] On the other hand, metal-mediated inactive C-H bond activation [including C(sp 3 )-H and C(sp 2 )-H bonds] has become a productive research field in organic and organometallic chemistry, [7] and this approach serves as one of the most powerful tools for the construction of carbon-carbon or carbon-heteroatom bonds. [8] However, only one or two C(sp 2 or sp 3 )ÀH bond is activated (the latter was also termed crossdehydrogenative-coupling, CGC) and forms a new carboncarbon or carbon-heteroatom single bond in most cases. [7d, 9] Examples of multiple CÀH bond activations for the construction of carbon-carbon or carbon-heteroatom double bonds are rare.…”

Palladium(II)‐Catalyzed Regioselective Ortho Arylation of sp2 CH Bonds of N‐Aryl‐2‐amino Pyridine Derivatives

“…Catalytic methods can realize such reactions. Prominent reactions in this regard are metal-catalyzed cross-coupling reactions of organo (pseudo) halides and various metal organyls 1. The great success of these reactions led to a Nobel Prize for Akira Suzuki, Richard Heck, and Ei-ichi Negishi in 2010.…”

Search for Highly Efficient, Stereoselective, and Practical Synthesis of Complex Organic Compounds of Medicinal Importance as Exemplified by the Synthesis of the C21C37 Fragment of Amphotericin B

“…Herein we report that (i) a highly efficient synthesis of a C32–C37 fragment ( 7 ) of ≥98% isomeric purity was achieved from ethyl ( S )-3-hydroxybutyrate by application of Brown crotylboration [9] and Fráter-Seebach alkylation, [10] (ii) highly selective and efficient syntheses of C21–C32 oligoene fragment of amphotericin B through appropriate uses of Horner-Wadsworth-Emmons reaction [11] (HWE reaction hereafter), alkyne hydrozirconation, [12] Pd-catalyzed Negishi coupling, [13] and Heck reaction [14] were discussed, (iii) the C21–C37 fragment ( 2 ) of amphotericin B was constructed in a highly concise and efficient strategy, which exemplify the high competence of delicate design of organic synthesis toward optimized synthesis of complex natural products.…”