Die Lokalisation des Gewebsaktivators der Fibrinolyse bei Dermatosen

Uf, Haustein

doi:10.1007/bf00504460

Cited by 27 publications

(7 citation statements)

References 37 publications

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“…In the present paper, our modified culture method may have satisfied the necessary conditions shown in the formula of Warburg as well as the factor (F) and thus maintained the psoriatic lesion in vitro. In the present experiments, psoriatic explants maintained not only their morphological characteristics but also their biochemical characteristics, including lowered isoproterenol-stimulated cAMP levels (20) and elevated plasminogen activator activity (21)(22)(23) in the involved psoriatic epidermis.…”

Section: Skin Explantsmentioning

confidence: 72%

Maintenance of Epidermal Structures of Psoriatic Skin in Organ Culture

Kondô

1986

The Journal of Dermatology

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A method for maintaining the epidermal structures of the normal human and uninvolved and involved psoriatic skin explants in organ culture was described. Skin explants were put in diffusion chambers made of millipore filters, which were then submitted to a roller tube culture at 15 rpm and 32°C. With a gas phase of air + 5% CO2 (phase A), both normal and psoriatic skin explants in culture showed parakeratosis or degeneration of their epidermal cells; with a gas phase of either 50% O2 + 45% N2 + 5% CO2 (phase B) or 95% O2 + 5% CO2 (phase C), they showed neither parakeratosis nor degeneration of epidermal cells and maintained their original structures for 14 days. Autoradiographically, the number of thymidine‐3H (3H‐TdR) labeled epidermal cells in organ culture was greater in involved psoriatic skin explants than in uninvolved ones. Isoproterenol‐stimulated cyclic AMP (cAMP) levels were lower in involved psoriatic epidermis of skin explants than in uninvolved ones, and plasminogen activator activity was higher in the former than in the latter. Addition of dexamethasone normalized the keratinization of the involved psoriatic explant in culture, but addition of dibutyryl cyclic AMP (db cAMP) and dibutyryl cyclic GMP (db cGMP) did not.

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Section: Skin Explantsmentioning

confidence: 72%

Maintenance of Epidermal Structures of Psoriatic Skin in Organ Culture

Kondô

1986

The Journal of Dermatology

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“…It has been suggested that fibrin deposits and loss of cutaneous fibrinolytic activity playa major role in the pathogenesis of many cutaneous diseases (CUNLIFFE 1968;RYAN 1976;HAUSTEIN 1969;LOTTI et al 1979LOTTI et al , 1987PANCONESI et al 1982).…”

Section: Therapeutic Use Of Fibrinolytic Drugs In Dermatologic Dismentioning

confidence: 99%

Pharmacology of the Skin II

1989

Handbook of Experimental Pharmacology

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PrefaceThe recent interest in the pharmacology of the skin and the treatment of its diseases has come about for two reasons. The first is a realisation that many aspects of pharmacology can be studied as easily in human skin as in animal models, where they may be more relevant to human physiology and disease. Examples of this are the action of various vasoactive agents and the isolation of mediators of inflammation after UV irradiation and antigen-induced dermatitis. The second reason is the fortuitous realisation that a pharmacological approach to the treatment of skin disease need not always await the full elucidation of aetiology and mechanism. For example, whilst the argument continued unresolved as to whether the pilo-sebaceous infection which constitutes acne was due to a blocked duct or to a simple increase in sebum production, 13-cis retinoic acid, was found quite by chance totally to ablate the disease; again, whilst cyclosporin, fresh from its triumphs in organ transplantation, has been found able to suppress the rash of psoriasis, it has resuscitated the debate on aetiology.We are therefore entering a new era in which the pharmacology and clinical pharmacology of skin are being studied as a fascinating new way of exploring questions of human physiology and pharmacology as well as for the development and study of new drugs, use of which will improve disease control and at the same time help to define pathological mechanisms.It was because of this burgeoning interest in pharmacology of skin and its diseases, that this book came about. Indeed it is long overdue and was planned several years ago; we console ourselves with the thought that the delay may have served to help define certain principles which were then only just emerging.The book is divided into two volumes which are independent but complementary; the first being an account of the general pharmacology of skin, the second volume being more concerned with disease and drugs. The first volume is divided into two parts, the one dealing with the pharmacology of skin systems and their control and the other with autocoids in normal and inflamed skin. This second volume has three parts; the first part deals with the methods of measurement which are becoming of increasing importance both in studying the pharmacological effects of drugs and the clinical pharmacology of skin; the second deals with toxicology in its widest sense -including metabolism and percutaneous absorption; and the third is an account both of specific drugs and the drugs used for specific diseases.

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“…Sir, Considering the paper on 'Pathogenetic Studies in Chronic Urticaria' by Boonk et al [1], I would like to refer to our studies which have partly been published in 1969 [2] and to our further experience [unpubl. data].…”

Section: Fibrinolysis In Chronic Urticariamentioning

confidence: 99%