“…This region has been noted as becom- ing progressively stretched (57), which may well be the essential stimulus to stromal proliferation; for the proportion of cortical stroma to primordial follicles varies inversely with cortical thickness (1). In time this stroma matures to the collagenized outer tunica, better adapted for resisting stretch, reducing later growth of the stroma and yielding the rough overall pattern of central radiate, middle interlacing and peripheral circumferential stroma (41,67).…”
Section: Discussionmentioning
confidence: 99%
“…These often remained tethered to the cortical lattice by a triangular proliferated cap ( Figs. 4 and 9), derived from it and giving rise centrally to the so-called "theca cone" (41,63). Such tethering only occurred after adequate formation of the lattice in the second half of the first year, and it caused some mediumsized follicles and their products to remain somewhat peripheral ( Figs.…”
Section: Middle Zonementioning
confidence: 99%
“…There is better evidence for a comparable conversion into macrophage like cells, both in prenatal (20) and postnatal (61) human ovaries and in those of lower vertebrates (18,23). General accounts of the architecture and form changes of the ovarian stroma have been given by several authors (4,7,12,16,41,46,47). from 2 weeks to 15 years, comprising 17 aged 2 weeks to 3 months, 15 from the rest of the first year, 7 from the second year, 8 aged 2-5, 15 aged 5-10 and 6 aged 10-15, furnishing bilateral pairs in seven only.…”
Ovarian development was studied in 113 patients ranging from birth to 15 years of age. After a short pause the ovary becomes highly active during the first year, subsides slowly to a trough between ages 3 and 5 and then resumes activity. During the early activity, central ripening follicles and their associated edema expand the ovary and then hold the ground gained by the progressive conversion during atresia of theca and some granulosa into medullary stroma. This later becomes amorphous and reduced in quantity. Cortical stroma forms separately and concurrently by proliferation of the interfollicular mesenchyme to form a lattice. Externally this matures to the tunica and internally anchors some ripening follicles to contribute retrogressed theca to its deeper layers. Cellular ovarian stroma probably develops as a proliferative response of loose ovarian mesenchyme to stretch, and so forms round individual ripening follicles and round the ovary as a whole stretched by the follicular complement and its associated edema. At both sites, therefore, its formation is dependent on the follicular mechanism. This explains the stromal poverty of dysgenetic and related ovaries and the stromal excess of Stein‐Leventhal ovaries, while the direct follicular ancestry of medullary and some deep cortical stroma may explain the proneness of these sites to develop lutein foci and tumors of specifically gonadal morphology. A note is added on “Pflüger's tubes,” which furnish a little cortical stroma and show disturbed development along with that of the ovary in prematurity, Turner's syndrome and mongolism.
“…This region has been noted as becom- ing progressively stretched (57), which may well be the essential stimulus to stromal proliferation; for the proportion of cortical stroma to primordial follicles varies inversely with cortical thickness (1). In time this stroma matures to the collagenized outer tunica, better adapted for resisting stretch, reducing later growth of the stroma and yielding the rough overall pattern of central radiate, middle interlacing and peripheral circumferential stroma (41,67).…”
Section: Discussionmentioning
confidence: 99%
“…These often remained tethered to the cortical lattice by a triangular proliferated cap ( Figs. 4 and 9), derived from it and giving rise centrally to the so-called "theca cone" (41,63). Such tethering only occurred after adequate formation of the lattice in the second half of the first year, and it caused some mediumsized follicles and their products to remain somewhat peripheral ( Figs.…”
Section: Middle Zonementioning
confidence: 99%
“…There is better evidence for a comparable conversion into macrophage like cells, both in prenatal (20) and postnatal (61) human ovaries and in those of lower vertebrates (18,23). General accounts of the architecture and form changes of the ovarian stroma have been given by several authors (4,7,12,16,41,46,47). from 2 weeks to 15 years, comprising 17 aged 2 weeks to 3 months, 15 from the rest of the first year, 7 from the second year, 8 aged 2-5, 15 aged 5-10 and 6 aged 10-15, furnishing bilateral pairs in seven only.…”
Ovarian development was studied in 113 patients ranging from birth to 15 years of age. After a short pause the ovary becomes highly active during the first year, subsides slowly to a trough between ages 3 and 5 and then resumes activity. During the early activity, central ripening follicles and their associated edema expand the ovary and then hold the ground gained by the progressive conversion during atresia of theca and some granulosa into medullary stroma. This later becomes amorphous and reduced in quantity. Cortical stroma forms separately and concurrently by proliferation of the interfollicular mesenchyme to form a lattice. Externally this matures to the tunica and internally anchors some ripening follicles to contribute retrogressed theca to its deeper layers. Cellular ovarian stroma probably develops as a proliferative response of loose ovarian mesenchyme to stretch, and so forms round individual ripening follicles and round the ovary as a whole stretched by the follicular complement and its associated edema. At both sites, therefore, its formation is dependent on the follicular mechanism. This explains the stromal poverty of dysgenetic and related ovaries and the stromal excess of Stein‐Leventhal ovaries, while the direct follicular ancestry of medullary and some deep cortical stroma may explain the proneness of these sites to develop lutein foci and tumors of specifically gonadal morphology. A note is added on “Pflüger's tubes,” which furnish a little cortical stroma and show disturbed development along with that of the ovary in prematurity, Turner's syndrome and mongolism.
“…recorded in the human ovary by Petry (1950) and in the ovary of the impala by Kayanja (1972). In the depth of the ovarian cortex, the reticular fibres were interwoven to form a three-dimensional system in which the follicles were lodged.…”
Investigations of the reproductive tracts of thirty-five female Procavia collected in the Kenya Rift Valley over a 1-year period are reported. The seasonal nature of breeding in these populations is confirmed. Parturition is followed by a period of lactation anoestrus. The appearance and internal structure of the ovary is described, together with an account of oogenesis and follicular development. Follicle and oocyte are large at the end of the first phase of growth, possibly due to the accumulation of lipid droplets in the oocyte. There was a high incidence of transuterine migration of ova in these animals. Considerable atresia of tertiary follicles during early pregnancy was noted. The ovary of Procavia shows general similarities to that of Dendrohyrax.
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