Die Kondensation von p ‐ und o ‐Methoxy‐mandelsäurenitril mit Phenolen und Phenoläthern

Abstract

O/O des angewandten Ketons; eine weitere Menge liiBt sich als 8 -P h e n y l v a l e r i nn s i i u r e -m e t h y l e s t e r (farbloses 01, Sdp.35 : 173 O) aus den nicht erstarrenden Oxydationsprodulrten des Methyl-6-pheny Ibutyl-ketons abscheiden. 0.2742 g Sbst.: 0.7460 g COs, 0.1950 g HaO. C l l H 1 4 0~. Bar. C 74.11, H '7.92. Gef B 7420, s 7.95. Uber einige andere d-Phenylvalerylketone und ihre Abwandlungen bolfe ich demnlchst berichten zu kiinnen. 537. A. B i e t r s y o k i , J. Paulus und R. Perrin: Die Kondensation von p-&d o-Methoxy-mandels8menitril mit Phenolen und Phenolilthern. 1) B i s t r z p c k i und Flatau, B. 28, 989 [l895]; 30, 1'24 [1897]; Cramer, B. 31, 2813 118981: S i m o n i s , B. 31, 2821 [1898]: von Tymieniecki, Dissertation, Freiburg (Schweiz) [1895]; Thomm e s e n , Dissertation, Freiburg (Schweiz) [1898]. 1) B. 81, 2812 [18983.3) Das Nitril lieferte allerdings eine weit geringere Ausberite an p-Oxysiurc rls die Mandelsiture selbst; vergl. den SchluD dieser Abhandlung.

The Reaction of Some Olefin Oxides With the Naphthols

“…The lactone of to-(2-hydroxy-l-naphthyl)-p-methoxyphenylacetic acid (1.2 g., 0.004 mole, m.p. 143-145°), prepared by the method of Bistrzycki (17), was added to lithium aluminum hydride (0.5 g., 0.013 mole) in dry ether (50 ml.). The mixture was warmed on the steam-bath for two hours and then was worked up in the usual manner.…”

Synthetic and biosynthetic approaches to cherylline and related compounds

“…The main concern of any such proof of structure synthesis is that the reactions proceed in a well-understood manner to produce products which distinguish between the different possibilities. The condensation which initiated the first successful synthetic sequence is derived from a literature procedure (35) for condensation of methoxymandelonitriles with phenols and phenolic ethers in a reaction medium of 73% sulfuric acid.…”

Synthetic and biosynthetic approaches to cherylline and related compounds

“…The The condensation which initiated the first successful synthetic sequence is derived from a literature procedure (35) for condensation of methoxymandelonitriles with phenols and phenolic ethers in a reaction medium of 73% sulfuric acid.…”