Die Kobalttherapie

Abstract

Die Spurenelementforschung der jüngsten Vergangenheit hat ein bisher wenig beachtetes Element in den Vordergrund treten lassen, das Metall Kobalt. Sein Vorkommen im Belebten ist zwar schon lange bekannt, seine Wirkung an Tier und Mensch erst in den letzten Jahren genauer untersucht. Das hiiufigere Auftreten

Case of cobalt poisoning.

“…Though cobalt is often effective in raising the haemoglobin, its mode of action is not known, but it may act by causing direct anoxia of the bone-marrow cells by enzyme inhibition (Weissbecker, 1950). Gardner (1953) and Kriss et al (1955) reported certain sideeffects after administration of cobalt even for short periods.…”

Concentration of Wear Products in Hair, Blood, and Urine after Total Hip Replacement

“…Neurological, renal, and cardiovascular changes occurring after the administration of cobalt and certain of its salts to man and animals have been reported (Weissbecker, 1950;Gardner, 1953;Holly, 1955;Kriss, et al, 1955;De Moraes and Mariano, 1967;Schirrmacher, 1967;Hall and Smith, 1968;Schroeder and Nason, 1969). Because of the histological findings and clinical reports it was thought that a long-term study of the distribution and route of excretion of the wear products in patients with T.H.Rzs was required.…”

Pharmacokinetics and selected pharmacodynamics of cobalt following a single intravenous administration to horses

“…[7] Cobalt acts by stabilizing a factor known as hypoxia inducible factor 1α (HIF1α). [8] While effective in the treatment of anaemia, chronic administration of cobalt, presumably due to deposition of cobalt in tissues and organs, has been associated with a number of toxic effects, which has limited its use as a therapeutic agent. Under normoxic conditions, HIF1α is rapidly degraded.…”