Die Knochenbank Richtlinien - Probleme - Anwendung

Abstract

Schliisselw6rter: Knochenbank 9 Richtlinien 9 Probleme -Anwendung Bone Banks: Guidelines -Problems -Application Abstract: Bone banks, which, due to problems concerning transmission of infectious diseases, had been shut down in many places over the last 10 years, are becoming increasingly popular all over the world again. Using different methods of virus inactivation either osteoconductivity is dramatically reduced or sterility of the transplant cannot be guaranteed. Synthetic bone replacement materials, which in addition to finally being bioresorbable also get better in terms of biomechanical stability all the time (SRS | ,,fracture grout | [Norian], alpha BSM | [Merck]) will not be able to take place neither for allogenous nor autogenous bone transplants during the next couple of years, until patient and material outcome has been evaluated over an adequate time frame. Autogenous bone transplantation therefore remains the golden standard, whereas allogenous transplantation has to be considered if cancellous bone explant sites have been exploited. In this case the guidelines of the Bundes~irztekammer from 1996 have to be applied. In the following these guidelines will be explained, occurring problems and possible solutions will be described and compared to the experiences made in other countries. Finally the use of such a bone bank will be analyzed together with a case history of polyostotic fibrous dysplasia in McCune-Albright's syndrome,

Einheilung autogener Transplantate nach dorsoventraler Instrumentierung instabiler Frakturen der thorakolumbalen Wirbels�ule

“…Allogene Transplantate haben sich für orthopädische Indikationen im klinischen Einsatz bewährt [34]. Berück-sichtigt werden muss allerdings der hohe Aufwand in der Betreibung von Knochenbanken und das, wenn auch geringe, Restrisiko einer Übertragung humanpathogener Keime [39].…”

Enhancing Bone Infection Diagnosis with Raman Handheld Spectroscopy: Pathogen Discrimination and Diagnostic Potential

“…The technique of bone grafting is frequently utilized in orthopedic surgery to encourage spinal fusion and reconstruct bone defects resulting from a range of factors, including trauma, tumors, or revision arthroplasty [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. Human bone allografts are frequently used to repair skeletal defects, as these induce bone remodeling and prevent early implant subsidence.…”

“…Treatment of these infections is challenging and often necessitates multiple surgical interventions [ 20 , 21 ]. PJI, for example, is a devastating condition, with fatality rates comparable to those of breast cancer and melanoma [ 8 ]. Coagulase-negative Staphylococci (CoNS), particularly Staphylococcus epidermidis , and then Staphylococcus aureus and mixed flora are the most common microbes in bone- and implant-related infections [ 14 , 22 , 23 ].…”

Comparison of Mid-Infrared Handheld and Benchtop Spectrometers to Detect Staphylococcus epidermidis in Bone Grafts

“…Bone represents the second most commonly transplanted tissue behind blood [ 1 ]. In orthopedic surgery, the application of human bone allografts is prevalent in promoting spinal fusion and reconstructing bone defects resulting from trauma, tumors, or revision arthroplasty [ 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. Removing loose implants and adjacent fibro cellular membranes is often necessary in the context of hip arthroplasty revision procedures.…”