“…One of the first clinical observations of patients with prefrontal lesions was of “Spontanstummheit” ( Kleist et al, 1940 ), which denotes a lack of spontaneous mental activity. In a recent study, Bertossi and Ciaramelli (2016) examined mind-wandering in patients with vmPFC damage.…”
Section: Functions Typically Linked With the Vmpfcmentioning
confidence: 99%
“…From the earliest neuropsychological studies of patients with frontal lobe lesions, a curious phenomenon was reported, that of confabulation ( Kleist et al, 1940 ). Confabulation, sometimes referred to as “honest lying” ( Moscovitch, 1989 ), is the unintentional production of false memories.…”
Section: Functions Typically Linked With the Vmpfcmentioning
HighlightsThe vmPFC and hippocampus are closely connected brain regions whose functions are still debated.Here we directly compared the cognitive changes in humans with either bilateral hippocampal or bilateral vmPFC damage.Hippocampal and vmPFC damage both affect classic ‘hippocampal’ tasks such as autobiographical memory recall.Hippocampal and vmPFC damage have opposite effects on classic ‘vmPFC’ tasks such as moral decision making.We propose a hierarchical network model where vmPFC initiates mental imagery including hippocampal scene construction.
“…One of the first clinical observations of patients with prefrontal lesions was of “Spontanstummheit” ( Kleist et al, 1940 ), which denotes a lack of spontaneous mental activity. In a recent study, Bertossi and Ciaramelli (2016) examined mind-wandering in patients with vmPFC damage.…”
Section: Functions Typically Linked With the Vmpfcmentioning
confidence: 99%
“…From the earliest neuropsychological studies of patients with frontal lobe lesions, a curious phenomenon was reported, that of confabulation ( Kleist et al, 1940 ). Confabulation, sometimes referred to as “honest lying” ( Moscovitch, 1989 ), is the unintentional production of false memories.…”
Section: Functions Typically Linked With the Vmpfcmentioning
HighlightsThe vmPFC and hippocampus are closely connected brain regions whose functions are still debated.Here we directly compared the cognitive changes in humans with either bilateral hippocampal or bilateral vmPFC damage.Hippocampal and vmPFC damage both affect classic ‘hippocampal’ tasks such as autobiographical memory recall.Hippocampal and vmPFC damage have opposite effects on classic ‘vmPFC’ tasks such as moral decision making.We propose a hierarchical network model where vmPFC initiates mental imagery including hippocampal scene construction.
“…2018 ; Barry and Maguire 2019a , 2019 b ). The occurrence of confabulation, along with reduced instigation of spontaneous thoughts more generally following vmPFC damage ( Kleist et al. 1940 ; Bertossi and Ciaramelli 2016 ; McCormick, Ciaramelli, et al.…”
Our ability to recall past experiences, autobiographical memories (AMs), is crucial to cognition, endowing us with a sense of self and underwriting our capacity for autonomy. Traditional views assume that the hippocampus orchestrates event recall, whereas recent accounts propose that the ventromedial prefrontal cortex (vmPFC) instigates and coordinates hippocampal-dependent processes. Here we sought to characterize the dynamic interplay between the hippocampus and vmPFC during AM recall to adjudicate between these perspectives. Leveraging the high temporal resolution of magnetoencephalography, we found that the left hippocampus and the vmPFC showed the greatest power changes during AM retrieval. Moreover, responses in the vmPFC preceded activity in the hippocampus during initiation of AM recall, except during retrieval of the most recent AMs. The vmPFC drove hippocampal activity during recall initiation and also as AMs unfolded over subsequent seconds, and this effect was evident regardless of AM age. These results recast the positions of the hippocampus and the vmPFC in the AM retrieval hierarchy, with implications for theoretical accounts of memory processing and systems-level consolidation.
“…The sophisticated descriptions of catatonic and akinetic-hyperkinetic syndromes cover 57 psychomotor signs and symptoms[ 31 , 32 ]. A number of cross-sectional and large-scale, long-term (15-20 years) follow-up studies conducted by Kleist, Leonhard and their co-workers confirmed the reliability and stability of Leonhard’s classification[ 31 , 32 , 34 - 37 ].…”
Section: Distinct Catatonia Subtypes As Putative Nosological Entitiesmentioning
Kahlbaum was the first to propose catatonia as a separate disease following the example of general paresis of the insane, which served as a model for establishing a nosological entity. However, Kahlbaum was uncertain about the nosological position of catatonia and considered it a syndrome, or “a temporary stage or a part of a complex picture of various disease forms”. Until recently, the issue of catatonia as a separate diagnostic category was not entertained, mainly due to a misinterpretation of Kraepelin’s influential views on catatonia as a subtype of schizophrenia. Kraepelin concluded that patients presenting with persistent catatonic symptoms, which he called “genuine catatonic morbid symptoms”, particularly including negativism, bizarre mannerisms, and stereotypes, had a poor prognosis similar to those of paranoid and hebephrenic presentations. Accordingly, catatonia was classified as a subtype of dementia praecox/schizophrenia. Despite Kraepelin’s influence on psychiatric nosology throughout the 20th century, there have only been isolated attempts to describe and classify catatonia outside of the Kraepelinian system. For example, the Wernicke-Kleist-Leonhard school attempted to comprehensively elucidate the complexities of psychomotor disturbances associated with major psychoses. However, the Leonhardian categories have never been subjected to the scrutiny of modern investigations. The first three editions of the DSM included the narrow and simplified version of Kraepelin’s catatonia concept. Recent developments in catatonia research are reflected in DSM-5, which includes three diagnostic categories: Catatonic Disorder due to Another Medical Condition, Catatonia Associated with another Mental Disorder (Catatonia Specifier), and Unspecified Catatonia. Additionally, the traditional category of catatonic schizophrenia has been deleted. The Unspecified Catatonia category could encourage research exploring catatonia as an independent diagnostic entity.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.