Die isolierte Neurofibromatose der Harnblase

Wiedemann, Andreas; Jaussi, R.; Rabs, U.

doi:10.1007/s00120-005-0921-6

Cited by 4 publications

(3 citation statements)

References 6 publications

(3 reference statements)

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“…Neurofibroma of the bladder is a rare condition with few reported cases [2,9,10,12,14,17] in the literature and neurofibromatosis of the bladder resulting in vesicovaginal fistula has not been previously reported to the best of our knowledge after a thorough literature search. The first case of bladder and spinal neurofibromatosis was reported by Gerhardt in 1878 [12].…”

Section: Discussionmentioning

confidence: 97%

“…Bladder neurofibromatosis may present as a diffuse infiltrative process or an isolated neurofibroma. The symptoms vary, ranging from urinary incontinence to retention [10,14,15]. We are not aware to the best of our knowledge of any case of vesicovaginal fistula that resulted from neurofibromatosis with bladder involvement.…”

Section: Introductionmentioning

confidence: 97%

“…Neurofibromas of the genital tract are commonly found in the vulva, clitoris and labia but rarely found in vagina, cervix, endometrium and myometrium [13][14][15]. Bladder neurofibromatosis may present as a diffuse infiltrative process or an isolated neurofibroma.…”

Section: Introductionmentioning

confidence: 99%

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Spontaneous Vesicovaginal Fistula in Neurofibromatosis: A Case Report

Ekwedigwe¹,

Adeoye²,

Daniyan³

et al. 2017

Gynecol Obstet

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Background: Neurofibromatosis type 1 is an autosomal dominant transmitted disease with various forms of clinical presentation. It commonly affects the skin and the nervous system. Involvement of the genitourinary system is rare. The bladder is the most commonly affected organ in the urinary system. Vesicovaginal fistula presenting as continuous leakage of urine per vagina is a rare urogenital manifestation of neurofibromatosis which has not been previously reported to the best of our knowledge. Vesicovaginal fistula is not a usual complication of urethral catheterization. Our aim is to report a rare case of vesicovaginal fistula in a patient with neurofibromatosis.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

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Spontaneous Vesicovaginal Fistula in Neurofibromatosis: A Case Report

Ekwedigwe¹,

Adeoye²,

Daniyan³

et al. 2017

Gynecol Obstet

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Primäres diffuses Neurofibrom der Harnblase

Rink

Minner

Mc³

et al. 2010

Urologe

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Diffuse neurofibromas are benign mesenchymal tumours with nerve sheath differentiation. Only a few cases have been reported in the urinary bladder. We present a well-documented case report of a 62-year-old man presenting with gross haematuria and histopathological confirmation of a diffuse neurofibroma. We further reviewed the current literature with regard to clinical features and treatment options.

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Benign Nerve Sheath Tumors on Urinary Bladder Biopsy

Wang¹,

Montgomery²,

Epstein³

2008

American Journal of Surgical Pathology

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Benign nerve sheath tumors (schwannoma and neurofibroma) involving the urinary bladders are rare with only case reports and limited series. We identified 6 neurofibromas and 2 schwannomas involving the urinary bladder. Of the 8 cases, 7 were sent to one of the authors in consultation and the last came for treatment to The Johns Hopkins Hospital. Patients (3 males, 5 females) ranged in age from 3 to 69 years old (average 36 y old). Presenting symptoms included recurrent infection in 6 patients, hematuria in 3 patients, and irritative symptoms in 3 patients (some patients with 2 symptoms). Three patients had a pelvic mass on physical examination. Three patients (3/8) had a solitary lesion in the bladder, 4 patients (4/8) had multifocal lesions, and 1 patient had no information available. Five patients underwent local resection. One patient, who was 3 years old, had multiple plexiform neurofibromas within the bladder and did not have surgical treatment and another patient is also undergoing surveillance. One patient had no treatment information available. Seven patients had clinical follow-up information available. The length of follow-up varied from 2 to 124 months (average 47 mo). Three out of the seven patients with follow-up information had neurofibromas in other sites, including the skin, uterus, mesentery, and ureter. One patient was known to have other stigmata of neurofibromatosis. Both cases with schwannoma had only bladder involvement. No family history of neurofibromatosis and no genetic studies were performed on any of the patients. Three neurofibromas were of the diffuse type, with 2 cases plexiform, and 1 case could not be subtyped. Neither recurrence nor malignant transformation was demonstrated on follow-up. The importance of accurately diagnosing plexiform neurofibromas of the bladder is that a subset harbors neurofibromatosis. If the lesion is focal, conservative excision is the choice of treatment with a low risk of recurrence. Diffuse neurofibromas can be difficult to diagnose leading to delay of treatment and potentially the need for a more extensive excision. Once recognized as a neurofibroma, it is important to identify it as a diffuse neurofibroma, given its lack of relationship to neurofibromatosis.

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Die isolierte Neurofibromatose der Harnblase

Cited by 4 publications

References 6 publications

Spontaneous Vesicovaginal Fistula in Neurofibromatosis: A Case Report

Spontaneous Vesicovaginal Fistula in Neurofibromatosis: A Case Report

Primäres diffuses Neurofibrom der Harnblase

Benign Nerve Sheath Tumors on Urinary Bladder Biopsy

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