Die Hirndurchblutung unter Neuroleptanaesthesie

Thiopentone Supplemented Anaesthesia for Neurosurgery

“…It has also been shown that the administration of droperidol and fentanyl will also substantially reduce cerebral blood flow (Miller and Barker, 1969). It is not entirely clear whether this effect is mediated through a reduction in cerebral metabolic rate as Kreuscher (1965) suggests, or whether the droperidol/fentanyl simply acts as a cerebral vasoconstrictor in its own right. It is interesting that the very early work on the effects of fentanyl on the cerebral circulation suggested that in fact it produced cerebral vasodilatation by excitation of the reticular activating system (Nilsson and Ingvar, 1965).…”